透明质酸与伤口愈合。
Hyaluronic acid and wound healing.
作者信息
Neuman Manuela G, Nanau Radu M, Oruña-Sanchez Loida, Coto Gabriel
机构信息
In Vitro Drug Safety and Biotechnology and Department of Pharmacology and Toxicology, University of Toronto.
出版信息
J Pharm Pharm Sci. 2015;18(1):53-60. doi: 10.18433/j3k89d.
BACKGROUND
We developed an experimental model of ethanol-induced dermatotoxicity and hepatocytoxicity using normal human keratinocytes and normal human hepatocytes that preserve inducible cytochrome p450 activities. The original work was described in several articles. The objective of this study was to determine whether hyaluronic acid attenuates skin necrosis, and to further clarify its uses in wound repair in humans, animal models and in vitro studies.
METHODS
We performed a systematic review of the literature using the terms "hyaluronic acid" and "wound healing". PubMed was searched for studies published during the period 2010-2014.
RESULTS
Hyaluronic acid is used in tissue regeneration alone or in combination with herbal or Western medicine. Scaffolds made up of hyaluronic acid were used to embed basic fibroblast growth factor.
CONCLUSION
Hyaluronic acid extracts are safe and efficacious products to be used in skin repair.
背景
我们利用保留诱导型细胞色素P450活性的正常人角质形成细胞和正常人肝细胞，建立了乙醇诱导的皮肤毒性和肝毒性实验模型。最初的研究成果发表在几篇文章中。本研究的目的是确定透明质酸是否能减轻皮肤坏死，并进一步阐明其在人类、动物模型和体外研究中伤口修复的用途。
方法
我们使用“透明质酸”和“伤口愈合”等术语对文献进行了系统综述。在PubMed上搜索了2010年至2014年期间发表的研究。
结果
透明质酸单独或与草药或西药联合用于组织再生。由透明质酸制成的支架被用于包埋碱性成纤维细胞生长因子。
结论
透明质酸提取物是用于皮肤修复的安全有效的产品。
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