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系统性红斑狼疮患者体内凝集素途径的丝氨酸蛋白酶及相关蛋白的血浆水平发生了改变。

Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus.

作者信息

Troldborg Anne, Thiel Steffen, Laska Magdalena Janina, Deleuran Bent, Jensenius Jens Christian, Stengaard-Pedersen Kristian

机构信息

From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.

出版信息

J Rheumatol. 2015 Jun;42(6):948-51. doi: 10.3899/jrheum.141163. Epub 2015 Apr 15.

DOI:10.3899/jrheum.141163
PMID:25877499
Abstract

OBJECTIVE

To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.

METHODS

Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).

RESULTS

Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).

CONCLUSION

In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.

摘要

目的

研究补体系统凝集素途径的蛋白质是否参与系统性红斑狼疮（SLE）的发病机制。

方法

采用时间分辨免疫荧光分析法，测定了58例SLE患者和65例健康对照（HC）血浆中甘露聚糖结合凝集素（MBL）相关丝氨酸蛋白酶1（MASP-1）、MASP-2、MASP-3、19 kDa的MBL相关蛋白（MAp19）和MAp44的水平。

结果

SLE患者血浆中MASP-1、MASP-3和MAp44的浓度高于HC（p < 0.0001、0.0003和0.0013）。补体因子3与MAp19水平呈负相关，抗双链DNA与MAp19水平呈正相关（p = 0.0035，p = 0.0133）。

结论

在SLE中，MASP和MAp的血浆水平发生改变，并与SLE的特征相关，支持其在SLE发病机制中的作用。

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