Asanuma Yuko, Nozawa Kazuhisa, Matsushita Masakazu, Kusaoi Makio, Abe Yoshiyuki, Yamaji Ken, Tamura Naoto
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Internal Medicine and Rheumatology, Juntendo University Koshigaya Hospital, Saitama, Japan.
Heliyon. 2023 Aug 10;9(8):e19072. doi: 10.1016/j.heliyon.2023.e19072. eCollection 2023 Aug.
In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE. As Mannose-binding lectin-associated serine proteases (MASPs) are associated with activation of the lectin pathway, we conducted this study to clarify MASPs associations in the pathogenesis of SLE. We evaluated the serum level of MASPs (MASP-1 and MASP-2) in total 68 SLE patients consisting of 15 patients with biopsy-confirmed membranous lupus nephritis (M-LN), 35 patients with biopsy-confirmed proliferative lupus nephritis (P-LN), and 18 SLE patients without LN (non-LN). Our data showed that the serum levels of MASPs were reduced in both P-LN and non-LN although those of M-LN were not reduced. Our data show that the lectin pathway mediated by MASPs plays a critical role for the pathogenesis of SLE except for M-LN.
在补体激活系统中，虽然经典途径已被证明在系统性红斑狼疮（SLE）的发病机制中起关键作用，但凝集素途径在SLE发病机制中的作用仍不清楚。由于甘露糖结合凝集素相关丝氨酸蛋白酶（MASPs）与凝集素途径的激活有关，我们开展了这项研究以阐明MASPs在SLE发病机制中的关联。我们评估了总共68例SLE患者的血清MASPs水平（MASP-1和MASP-2），其中包括15例经活检确诊为膜性狼疮性肾炎（M-LN）的患者、35例经活检确诊为增殖性狼疮性肾炎（P-LN）的患者以及18例无狼疮性肾炎的SLE患者（非LN）。我们的数据显示，P-LN组和非LN组患者的血清MASPs水平均降低，而M-LN组患者的血清MASPs水平未降低。我们的数据表明，除M-LN外，由MASPs介导的凝集素途径在SLE发病机制中起关键作用。
