Ko Chung-Po, Yang Li-Chiu, Chen Chih-Jung, Yeh Kun-Tu, Lin Shu-Hui, Yang Shun-Fa, Chen Mu-Kuan, Lin Chiao-Wen
Department of Neurosurgery, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Tumour Biol. 2015 Sep;36(9):7099-105. doi: 10.1007/s13277-015-3419-x. Epub 2015 Apr 16.
The myeloid zinc finger 1 (MZF1) is a zinc finger transcription factor which regulates myeloid differentiation and oncogenesis. However, little information is available concerning the MZF1 expression in oral squamous cell carcinoma (OSCC) and its correlation with patients' prognosis. We detected the expression of MZF1 in 274 patients with OSCC using tissue microarrays (TMAs) and evaluated the associations between nuclear MZF1 expression and the clinical parameters of OSCC patients. We found that nuclear MZF1 expression was present in 190/274 (69.3 %) cases, and loss of nuclear expression of MZF1 was associated with more advanced clinical stages (p = 0.011) and larger tumor size (p = 0.002), but not associated with positive lymph node metastasis and distal metastasis. Importantly, tongue squamous cell carcinomas (SCC) patients with negative nuclear MZF1 expression had significantly worse overall survival rates (log-rank test, p = 0.028). In conclusion, our results revealed that the loss of nuclear expression of MZF1 in OSCC samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan.
髓系锌指蛋白1（MZF1）是一种锌指转录因子，可调节髓系分化和肿瘤发生。然而，关于MZF1在口腔鳞状细胞癌（OSCC）中的表达及其与患者预后的相关性，目前所知甚少。我们使用组织微阵列（TMA）检测了274例OSCC患者中MZF1的表达，并评估了核MZF1表达与OSCC患者临床参数之间的关联。我们发现，190/274（69.3%）例患者存在核MZF1表达，MZF1核表达缺失与更晚期的临床分期（p = 0.011）和更大的肿瘤大小（p = 0.002）相关，但与阳性淋巴结转移和远处转移无关。重要的是，核MZF1表达阴性的舌鳞状细胞癌（SCC）患者的总生存率明显更差（对数秩检验，p = 0.028）。总之，我们的结果表明，OSCC样本中MZF1核表达缺失可预测台湾地区OSCC的进展和OSCC患者的生存情况。
