身体活动与多发性硬化症患者的认知处理速度有关。
Physical activity is associated with cognitive processing speed in persons with multiple sclerosis.
作者信息
Sandroff Brian M, Dlugonski Deirdre, Pilutti Lara A, Pula John H, Benedict Ralph H B, Motl Robert W
机构信息
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 233 Freer Hall, 906 South Goodwin Avenue, Urbana 61801, IL, United States.
Department of Neuro-Ophthalmology, University of Illinois College of Medicine at Peoria, United States; Illinois Neurologic Institute, United States.
出版信息
Mult Scler Relat Disord. 2014 Jan;3(1):123-8. doi: 10.1016/j.msard.2013.04.003. Epub 2013 May 23.
The impairment of cognitive processing speed is common, disabling, and poorly managed in multiple sclerosis (MS). This study examined the association between objectively-measured physical activity and cognitive processing speed (CPS) in a large sample of persons with MS. Patients (N=212) underwent two valid neuropsychological tests of CPS, completed the Timed 25-Foot Walk (T25FW), and wore an ActiGraph model GT3X accelerometer during the waking hours of a 7-day period for objectively measuring physical activity as steps/day. Physical activity was significantly associated with CPS (r=.39, p<.01), even when controlling for age, sex, and education (pr=.26, p<.01). This association was attenuated, but still significant after further controlling for T25FW performance (pr=.13, p=.03). Physical activity behavior is positively and independently, albeit weakly, associated with CPS in persons with MS, and may play an important role in managing this aspect of cognition as it does in other outcomes in MS.
认知加工速度受损在多发性硬化症（MS）中很常见，会导致残疾，且管理不善。本研究在一大群MS患者中检验了客观测量的身体活动与认知加工速度（CPS）之间的关联。患者（N = 212）接受了两项有效的CPS神经心理学测试，完成了25英尺定时步行（T25FW），并在7天的清醒时间里佩戴ActiGraph GT3X加速度计，以客观测量身体活动，单位为每天步数。即使在控制了年龄、性别和教育程度后，身体活动与CPS仍显著相关（r = 0.39，p < 0.01）（偏相关系数pr = 0.26，p < 0.01）。在进一步控制T25FW表现后，这种关联减弱，但仍然显著（pr = 0.13，p = 0.03）。身体活动行为与MS患者的CPS呈正相关且独立相关，尽管较弱，并且在管理MS的这一认知方面可能发挥重要作用，就像在MS的其他结果中一样。
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