Sandroff Brian M, Pilutti Lara A, Benedict Ralph H B, Motl Robert W
University of Illinois at Urbana-Champaign, Urbana, IL, USA.
University at Buffalo, State University of New York, Buffalo, NY, USA.
Neurorehabil Neural Repair. 2015 Mar-Apr;29(3):214-23. doi: 10.1177/1545968314541331. Epub 2014 Jul 8.
Cognitive impairment is a highly prevalent, poorly managed, and disabling consequence of multiple sclerosis (MS). Exercise training that improves physical fitness represents a promising approach for managing cognitive impairment in persons with MS. There is limited evidence that physical fitness is associated with multiple domains of cognitive dysfunction across levels of MS disability.
This cross-sectional study examined the associations among aerobic capacity, lower limb muscle strength, and cognitive functions in persons with mild, moderate, and severe MS disability.
The sample included 62 persons with mild (n = 20), moderate (n = 21), and severe (n = 21) MS disability. The participants underwent neuropsychological assessments of cognitive processing speed (CPS; Symbol Digit Modalities Test [SDMT]), verbal memory (California Verbal Learning Test-2 [CVLT-2]), and visual memory (Brief Visuospatial Memory Test-Revised [BVMT-R]). All participants further underwent testing for measuring aerobic capacity (ie, peak oxygen consumption) and muscular strength (ie, peak torque of knee flexors and extensors).
Aerobic capacity and muscular strength outcomes were associated with SDMT (r = .35-.41), but not CVLT-2 or BVMT-R (r < .19) scores in the overall sample. Aerobic capacity (r = .42) and knee flexor peak torque (r = .39) were associated with SDMT scores in persons with mild disability, but not in those with moderate (r < .06) and severe (r < .14) disability.
These results support examining aerobic and resistance exercise training programs for improving CPS, particularly among persons with mild MS disability.
认知障碍是多发性硬化症（MS）常见、治疗不佳且导致残疾的后果。改善体能的运动训练是管理MS患者认知障碍的一种有前景的方法。关于体能与MS残疾程度不同水平的多个认知功能障碍领域之间的关联，证据有限。
这项横断面研究调查了轻度、中度和重度MS残疾患者的有氧运动能力、下肢肌肉力量与认知功能之间的关联。
样本包括62名轻度（n = 20）、中度（n = 21）和重度（n = 21）MS残疾患者。参与者接受了认知加工速度（CPS；符号数字模式测验[SDMT]）、言语记忆（加利福尼亚言语学习测验第2版[CVLT - 2]）和视觉记忆（简短视觉空间记忆测验修订版[BVMT - R]）的神经心理学评估。所有参与者还接受了测量有氧运动能力（即峰值耗氧量）和肌肉力量（即膝部屈肌和伸肌的峰值扭矩）的测试。
在整个样本中，有氧运动能力和肌肉力量结果与SDMT相关（r = 0.35 - 0.41），但与CVLT - 2或BVMT - R分数无关（r < 0.19）。有氧运动能力（r = 0.42）和膝部屈肌峰值扭矩（r = 0.39）与轻度残疾患者的SDMT分数相关，但与中度（r < 0.06）和重度（r < 0.14）残疾患者无关。
这些结果支持研究有氧运动和抗阻运动训练方案以改善CPS，特别是在轻度MS残疾患者中。
