Chitturi Ravi Teja, Balasubramaniam A Murali, Parameswar R Arjun, Kesavan G, Haris K T Muhamed, Mohideen Khadijah
Senior Lecturer, Department of Oral Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
Senior Lecturer, Department of Oral Pathology, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India.
J Int Oral Health. 2015 Mar;7(3):75-80.
Myofibroblasts after its discovery in 1971 as the principal cell for wound healing has come a long way as far as research is concerned. The primary focus of research has been regarding preventing certain unwanted effects of this cell such as wound contraction and scarring. As far as the oral and maxillofacial region is concerned, the primary concern of this untoward effect is during repair of cleft palate surgically which results impaired development of palate and the dentoalveolar structures. This review focuses on the basic aspects of myofibroblasts such as its origin, formation, function in wound healing, role in wound contraction and ways by which its unwanted effects can be overcome to improve the quality of the post surgical complications of cleft palate surgery.
1971年肌成纤维细胞被发现是伤口愈合的主要细胞，就研究而言，其发展历程漫长。研究的主要重点一直是预防这种细胞的某些不良影响，如伤口收缩和瘢痕形成。就口腔颌面区域而言，这种不良影响的主要问题出现在腭裂手术修复过程中，这会导致腭部和牙槽结构发育受损。本综述聚焦于肌成纤维细胞的基本方面，如它的起源、形成、在伤口愈合中的功能、在伤口收缩中的作用以及可以克服其不良影响以改善腭裂手术术后并发症质量的方法。
