谷氨酰胺和缬沙坦对慢性心力衰竭患者脑钠肽及N末端B型利钠肽原的影响。
Effects of glutamine and valsartan on the brain natriuretic peptide and N-terminal pro-B-type natriuretic peptide of patients with chronic heart failure.
作者信息
Shao Mingliang, Huang Congxin, Li Zhen, Yang Hui, Feng Qifan
机构信息
Dr. Mingliang Shao, Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, People's Republic of China.
Dr. Congxin Huang, Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, People's Republic of China.
出版信息
Pak J Med Sci. 2015 Jan-Feb;31(1):82-6. doi: 10.12669/pjms.311.6302.
OBJECTIVE
To analyze the effects of glutamine and valsartan on the brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) of patients with chronic heart failure (CHF).
METHODS
A total of 140 CHF patients were divided into a treatment group and a control group by random drawing, and were subjected to standard anti-heart failure treatment and administered with valsartan. Besides, the treatment group was also intravenously transfused glutamine. The treatment lasted eight weeks.
RESULTS
The overall efficacy of treatment group and control group were 98.6% and 90.0% respectively, with a statistically significant difference (P<0.05). The two groups had significantly increased left ventricular ejection fractions as well as significantly decreased left ventricular end-diastolic volumes and left ventricular end-diastolic dimensions after treatments (P<0.05) compared with those before. There were also inter-group differences between these values (P<0.05). After treatment, the levels of BNP, NT-proBNP and CD8(+) in both groups significantly decreased (P<0.05), whereas those of CD4(+) significantly increased (P<0.05). The two groups also had significantly different values (P<0.05).
CONCLUSION
Glutamine in combination with valsartan enhanced the therapeutic effects by improving cardiac function, which may be associated with decreased expressions of BNP and NT-proBNP and beneficial effects of glutamine on immune function.
目的
分析谷氨酰胺和缬沙坦对慢性心力衰竭（CHF）患者脑钠肽（BNP）及N末端B型利钠肽原（NT-proBNP）的影响。
方法
将140例CHF患者通过随机抽签分为治疗组和对照组，均给予标准抗心力衰竭治疗并服用缬沙坦。此外，治疗组还静脉输注谷氨酰胺。治疗持续8周。
结果
治疗组和对照组的总有效率分别为98.6%和90.0%，差异有统计学意义（P<0.05）。两组治疗后左心室射血分数均显著升高，左心室舒张末期容积和左心室舒张末期内径均显著降低（P<0.05），且这些值组间也有差异（P<0.05）。治疗后，两组的BNP、NT-proBNP及CD8(+)水平均显著降低（P<0.05），而CD4(+)水平显著升高（P<0.05），两组这些值也有显著差异（P<0.05）。
结论
谷氨酰胺联合缬沙坦通过改善心功能增强治疗效果，这可能与BNP和NT-proBNP表达降低以及谷氨酰胺对免疫功能的有益作用有关。
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