Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Int J Mol Sci. 2019 Apr 12;20(8):1820. doi: 10.3390/ijms20081820.
Currently, brain natriuretic peptide (BNP) and -terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine. Several previous studies have reviewed BNP and NT-proBNP in clinical medicine, however, few articles have reviewed their application in forensic medicine. The present article reviews the biological features, the research and application status, and the future research prospects of BNP and NT-proBNP in both clinical medicine and forensic medicine, thereby providing valuable assistance for clinicians and forensic pathologists.
目前，脑钠肽（BNP）和 N 末端脑钠肽前体（NT-proBNP）被广泛用作临床医学中心力衰竭（HF）和心功能障碍的诊断生物标志物。它们也被用作法医学中反映死者生前心脏功能的死后生物标志物。之前的几项研究已经综述了 BNP 和 NT-proBNP 在临床医学中的应用，但是，很少有文章综述它们在法医学中的应用。本文综述了 BNP 和 NT-proBNP 在临床医学和法医学中的生物学特性、研究和应用现状以及未来的研究前景，为临床医生和法医病理学家提供了有价值的帮助。
