Albayrak Sebahattin, Zengin Kürsad, Tanik Serhat, Daar Ghaniya, Ozdamar Mustafa Yasar, Bakirtas Hasan, Imamoglu M Abdurrahim, Gurdal Mesut
Sebahattin Albayrak, MD. Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Kürsad Zengin, MD. Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Pak J Med Sci. 2015 Jan-Feb;31(1):87-90. doi: 10.12669/pjms.311.6424.
Folate, vitamin B12 and iron are important vitamin and minerals which play role in the development of nervous system. The aim of this study was looking at the presence of folate, vitamin B12 and iron deficiency among patients with Primary nocturnal enuresis (PNE) and possible relation between the delay of central nervous system (CNS) development, PNE and folate, vitamin B12 and iron states.
Consecutively applied forty patients with PNE (23 girls and 17 boys) and otherwise normal thirty control subjects (17 girls and 13 boys) were included in the study. Average ages (in range) of PNE and the control group were 9.2(6-12) years and 9.3 (6-12) years accordingly. Age, height, weight, complete blood count, blood vitamin B12, folate, ferritin and iron values of both groups were recorded and compared to each other.
Average vitamin B12 and folate levels of patients with PNE were significantly and statistically lower compared to those of the control group. Average blood iron of patients with PNE was significantly higher than that of the control group and also average ferritin level of the PNE group was detected to be higher than the control group but this relation was statistically insignificant.
Primary nocturnal enuresis is related to the delay in CNS maturation so it was thought that low vitamin B12 and folate which were found in patients with PNE may have role in the delay of CNS maturation. Additionally, further studies are needed to investigate the role of vitamin B12 and folate either alone or as combination in treatment of patients with PNE who have low vitamin B12and folate level.
叶酸、维生素B12和铁是重要的维生素和矿物质，在神经系统发育中发挥作用。本研究旨在探讨原发性夜间遗尿症（PNE）患者中叶酸、维生素B12和铁缺乏的情况，以及中枢神经系统（CNS）发育延迟、PNE与叶酸、维生素B12和铁状态之间的可能关系。
本研究连续纳入40例PNE患者（23例女孩和17例男孩）以及30例其他方面正常的对照受试者（17例女孩和13例男孩）。PNE组和对照组的平均年龄（范围）分别为9.2（6 - 12）岁和9.3（6 - 12）岁。记录两组的年龄、身高、体重、全血细胞计数、血液维生素B12、叶酸、铁蛋白和铁值，并进行相互比较。
与对照组相比，PNE患者的平均维生素B12和叶酸水平显著降低且具有统计学意义。PNE患者的平均血铁水平显著高于对照组，并且PNE组的平均铁蛋白水平也高于对照组，但这种关系无统计学意义。
原发性夜间遗尿症与中枢神经系统成熟延迟有关，因此认为PNE患者中发现的低维生素B12和叶酸可能在中枢神经系统成熟延迟中起作用。此外，需要进一步研究单独或联合使用维生素B12和叶酸对维生素B12和叶酸水平低的PNE患者治疗的作用。
