Wallace Eric, Maillard Nicolas, Ueda Hiroyuki, Hall Stacy, Fatima Huma, Novak Jan, Julian Bruce A
Division of Nephrology, Department of Medicine , University of Alabama at Birmingham , Birmingham, AL , USA.
Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
Clin Kidney J. 2014 Oct;7(5):479-83. doi: 10.1093/ckj/sfu090.
The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a case of a 67-year-old woman with rapidly rising serum creatinine, proteinuria and severe hypertension. The kidney biopsy findings included some features of IgA-dominant PIGN while others were more consistent with classical IgA nephropathy. We describe this patient's immune profile at the time of acute kidney injury and review the literature regarding differentiation of the two entities.
IgA 为主的感染后肾小球肾炎（PIGN）的诊断可能具有挑战性，因为它必须与活动性 IgA 肾病相鉴别。IgA 为主的 PIGN 的主要临床病理特征与活动性 IgA 肾病的特征有很大重叠。在此，我们报告一例 67 岁女性患者，其血清肌酐迅速升高、蛋白尿且患有严重高血压。肾脏活检结果包括一些 IgA 为主的 PIGN 的特征，而其他特征更符合经典 IgA 肾病。我们描述了该患者急性肾损伤时的免疫特征，并回顾了关于这两种疾病鉴别的文献。
