排列纳米结构阵列以控制生物大分子的平衡和非平衡输运。
Arrangement of a nanostructure array to control equilibrium and nonequilibrium transports of macromolecules.
机构信息
△ERATO Higashiyama Live-Holonics Project, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
§National Institute for Materials Science, Tsukuba 305-0044, Japan.
出版信息
Nano Lett. 2015 May 13;15(5):3445-51. doi: 10.1021/acs.nanolett.5b00783. Epub 2015 Apr 28.
Exploiting the nonequilibrium transport of macromolecules makes it possible to increase the separation speed without any loss of separation resolution. Here we report the arrangement of a nanostructure array in microchannels to control equilibrium and nonequilibrium transports of macromolecules. The direct observation and separation of macromolecules in the nanopillar array reported here are the first to reveal the nonequilibrium transport, which has a potential to overcome the intrinsic trade-off between the separation speed and resolution.
利用生物大分子的非平衡输运使得在不损失分离分辨率的情况下提高分离速度成为可能。在这里，我们报告了在微通道中排列纳米结构阵列以控制生物大分子的平衡和非平衡输运。这里报道的对纳米柱阵列中生物大分子的直接观察和分离首次揭示了非平衡输运，这有可能克服分离速度和分辨率之间的固有权衡。
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