Kim Evgenii, Lee Songhyun, Phillips Zephaniah, Kim Jae G
School of Information and Communications, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea.
Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea.
BMC Urol. 2015 Feb 21;15(1):11. doi: 10.1186/s12894-015-0005-x.
In this paper, we observed a discrepancy of penile hemodynamics dependent on location by using near infrared spectroscopy (NIRS) sensor, and showcase NIRS as a potentially suitable sensor in supplementing the diagnosis and treatment of erectile dysfunction.
To observe the effect that location has on penile hemodynamics, the NIRS sensor was placed on the top and the side of genital organ, and oxy- (HbO), deoxy-(RHb), and total (HbT) hemoglobin concentration changes were acquired. Our results from 6 healthy subjects show that hemodynamic changes vary depending on where the probe was placed. To observe a statistical difference between the signals, a Wilcoxon signed-rank test was performed.
The result shows a significant difference (p < 0.05) between concentration changes of RHb and HbT depending on the probes' location. Moreover, the sensor placed on the top of the organ shows a rise of HbO and HbT concentration while RHb concentration decreased. However, hemodynamics from the side of the organ showed that RHb concentration increased along with HbO.
The outcomes demonstrates an ability of NIRS to be sensitive enough to detect the different hemodynamic changes in various locations of a healthy male genital organ during visual sexual stimulation. The results also show the importance of sensor location on the genital organ for the resulting hemodynamic changes. We can foresee our results as a way for clinicians to obtain more accurate hemodynamic measurements from the penis, and also show the likelihood for NIRS enhanced diagnosis tool of male erectile dysfunction over the current standards.
在本文中，我们通过使用近红外光谱（NIRS）传感器观察到阴茎血流动力学因位置而异，并展示了NIRS作为一种潜在合适的传感器，可辅助勃起功能障碍的诊断和治疗。
为了观察位置对阴茎血流动力学的影响，将NIRS传感器放置在生殖器官的顶部和侧面，并获取氧合血红蛋白（HbO）、脱氧血红蛋白（RHb）和总血红蛋白（HbT）浓度的变化。我们对6名健康受试者的研究结果表明，血流动力学变化因探头放置位置而异。为了观察信号之间的统计学差异，进行了Wilcoxon符号秩检验。
结果显示，根据探头位置不同，RHb和HbT的浓度变化存在显著差异（p < 0.05）。此外，放置在器官顶部的传感器显示HbO和HbT浓度升高，而RHb浓度降低。然而，从器官侧面测得的血流动力学结果显示，RHb浓度随HbO浓度升高。
这些结果表明，NIRS能够灵敏地检测到在视觉性刺激期间健康男性生殖器官不同位置的血流动力学变化。结果还显示了传感器在生殖器官上的位置对血流动力学变化的重要性。我们可以预见，我们的结果为临床医生提供了一种从阴茎获取更准确血流动力学测量的方法，同时也显示了NIRS作为男性勃起功能障碍诊断工具优于现有标准的可能性。
