Arora Tarun, Rehan Harmeet Singh
J Basic Clin Physiol Pharmacol. 2015 Sep;26(5):427-31. doi: 10.1515/jbcpp-2014-0116.
Recent concerns on increased incidence of myocardial infarction and stroke on administration of calcium and vitamin D supplements have alarmed the physicians about safety of these drugs. Although both calcium and vitamin D have been shown in the past to have beneficial effect on cardiovascular disease status through lowering of harmful lipids, these findings have been contradicted by some recent meta-analysis and randomized controlled trials that have shown no beneficial or in some cases a deteriorating effect of these supplements on lipid levels. In particular, calcium supplementation has been associated more with increased incidence of cardiovascular morbidity than vitamin D, but the convincing proof is still lacking. Here we have highlighted the results of some significant studies that might impact the prescription of these drugs.
近期关于服用钙和维生素D补充剂后心肌梗死和中风发病率增加的担忧，使医生们对这些药物的安全性感到警觉。尽管过去已表明钙和维生素D通过降低有害血脂对心血管疾病状况有有益作用，但最近的一些荟萃分析和随机对照试验与这些发现相矛盾，这些分析和试验表明这些补充剂对血脂水平没有有益影响，在某些情况下甚至有恶化作用。特别是，与维生素D相比，补钙与心血管疾病发病率增加的关联更为密切，但仍缺乏确凿证据。在此，我们着重介绍了一些可能影响这些药物处方的重要研究结果。
