Department of Health Professions, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester M15 6BG, UK.
Department of Exercise & Sport Science, Manchester Metropolitan University, Crewe, Cheshire CW1 5DU, UK.
Nutrients. 2018 Nov 2;10(11):1642. doi: 10.3390/nu10111642.
A number of food micronutrients are reported to influence markers of cardio-metabolic health. There is an expectation that there may be an optimal endocrine profile, with triglycerides as a key factor, which may help minimise atherosclerotic disease and associated risk factors. This study involved 84 participants aged (mean ± SD) 48.2 ± 8.3 years from both sexes segregated into = 30 controls, = 25 at-risk, and = 29 diagnosed with atherosclerosis, including 20 participants using statins. Atherosclerosis status and risk factors were assessed using a combination of clinical records, C-reactive protein (CRP), blood glucose (FBG), lipids profiles, vascular structural and functional characteristics (including carotid-radial pulse wave velocity (CR-PWV), central systolic blood pressure (C-SBP), peripheral systolic blood pressure (P-SBP), peripheral diastolic blood pressure (P-DBP), carotid intima-media thickness (IMT), and carotid artery inter-adventitial diameter (IAD)). There was a significant difference in triglycerides (TG) levels between the clinical groups ( < 0.05) and between the users and non-users of statin ( < 0.001). Significant associations were distinguished between TG and CRP, FBG, high-density lipoprotein (HDL), C-SBP, P-SBP, P-DBP, CR-PWV, heart rate (HR), and body weight in the pooled sample ( < 0.05). In non-users of statin, TG was associated with C-SBP, P-SBP, P-DBP, and HR. In sub-clinical groups, TG was also associated with most of the blood markers. After controlling for statin use, composite z-score analysis revealed 48%, 2%, and 0% differences in in vivo vascular phenotype between high and low TG subgroups in controls, at-risk, and diagnosed atherosclerosis groups, respectively. Thus, TG levels seem to be good indicators for incidence and risk factors of atherosclerosis.
一些食物微量营养素据报道会影响心血管代谢健康的标志物。人们期望存在一个最佳的内分泌谱，其中甘油三酯是一个关键因素，这可能有助于最大限度地减少动脉粥样硬化疾病和相关的危险因素。本研究涉及 84 名年龄在（平均 ± 标准差）48.2 ± 8.3 岁的参与者，分为 30 名对照组、25 名高危组和 29 名诊断为动脉粥样硬化组，其中 20 名参与者使用他汀类药物。通过结合临床记录、C 反应蛋白（CRP）、血糖（FBG）、血脂谱、血管结构和功能特征（包括颈动脉-桡动脉脉搏波速度（CR-PWV）、中心收缩压（C-SBP）、外周收缩压（P-SBP）、外周舒张压（P-DBP）、颈动脉内膜中层厚度（IMT）和颈动脉壁间直径（IAD））评估动脉粥样硬化的状况和危险因素。在临床组之间（ < 0.05）和他汀类药物使用者和非使用者之间（ < 0.001），甘油三酯（TG）水平存在显著差异。在汇总样本中，TG 与 CRP、FBG、高密度脂蛋白（HDL）、C-SBP、P-SBP、P-DBP、CR-PWV、心率（HR）和体重之间存在显著关联（ < 0.05）。在他汀类药物非使用者中，TG 与 C-SBP、P-SBP、P-DBP 和 HR 相关。在亚临床组中，TG 也与大多数血液标志物相关。在控制他汀类药物使用后，复合 z 分数分析显示，在对照组、高危组和诊断为动脉粥样硬化组中，高 TG 亚组和低 TG 亚组之间的体内血管表型差异分别为 48%、2%和 0%。因此，TG 水平似乎是动脉粥样硬化发病和危险因素的良好指标。
