El Daker Sary, Sacchi Alessandra, Tempestilli Massimo, Carducci Claudia, Goletti Delia, Vanini Valentina, Colizzi Vittorio, Lauria Francesco Nicola, Martini Federico, Martino Angelo
Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy; Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
PLoS One. 2015 Apr 16;10(4):e0123772. doi: 10.1371/journal.pone.0123772. eCollection 2015.
Tuberculosis (TB) is still the principal cause of death caused by a single infectious agent, and the balance between the bacillus and host defense mechanisms reflects the different manifestations of the pathology. The aim of this work was to study the role of myeloid-derived suppressor cells (MDSCs) during active pulmonary tuberculosis at the site of infection. We observed an expansion of MDSCs in the lung and blood of patients with active TB, which are correlated with an enhanced amount of nitric oxide in the plasma. We also found that these cells have the remarkable ability to suppress T-cell response, suggesting an important role in the modulation of the immune response against TB. Interestingly, a trend in the diminution of MDSCs was found after an efficacious anti-TB therapy, suggesting that these cells may be used as a potential biomarker for monitoring anti-TB therapy efficacy.
结核病（TB）仍然是由单一传染源导致死亡的主要原因，杆菌与宿主防御机制之间的平衡反映了病理学的不同表现形式。这项工作的目的是研究髓系来源的抑制性细胞（MDSCs）在活动性肺结核感染部位所起的作用。我们观察到活动性肺结核患者的肺部和血液中MDSCs有所增加，这与血浆中一氧化氮含量的增加相关。我们还发现这些细胞具有显著抑制T细胞反应的能力，表明其在调节针对结核病的免疫反应中发挥重要作用。有趣的是，在有效的抗结核治疗后发现MDSCs有减少的趋势，这表明这些细胞可能用作监测抗结核治疗疗效的潜在生物标志物。
