益生菌对心理健康和下丘脑-垂体-肾上腺轴的影响：一项针对石化工人的随机、双盲、安慰剂对照试验。
The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers.
作者信息
Mohammadi Ali Akbar, Jazayeri Shima, Khosravi-Darani Kianoush, Solati Zahra, Mohammadpour Nakisa, Asemi Zatollah, Adab Zohre, Djalali Mahmoud, Tehrani-Doost Mehdi, Hosseini Mostafa, Eghtesadi Shahryar
机构信息
a Department of Nutrition, School of Public Health , Iran University of Medical Sciences , Tehran , Iran.
b Research Department of Food Technology Research , National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran.
出版信息
Nutr Neurosci. 2016 Nov;19(9):387-395. doi: 10.1179/1476830515Y.0000000023. Epub 2015 Apr 16.
OBJECTIVE
The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers.
METHODS
The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt + one placebo capsule (n = 25) or one probiotic capsule daily + 100 g/day conventional yogurt (n = 25) or 100 g/day conventional yogurt + one placebo capsule (n = 20) for 6 weeks. Mental health parameters including general health questionnaire (GHQ) and depression anxiety and stress scale (DASS) scores were measured. Fasting blood samples were obtained at the beginning and 6 weeks after the intervention to quantify hypothalamic-pituitary-adrenal axis.
RESULTS
After 6 weeks of intervention, a significant improvement of GHQ was observed in the probiotic yogurt (18.0 ± 1.5 vs. 13.5 ± 1.9, P = 0.007) and in the probiotic capsule group (16.9 ± 1.8 vs. 9.8 ± 1.9, P = 0.001), as well as a significant improvement in DASS scores in the probiotic yogurt (23.3 ± 3.7 vs. 13.0 ± 3.7, P = 0.02) and the probiotic capsule group (18.9 ± 3.2 vs. 9.4 ± 4.0, P = 0.006). However, there was no significant improvement in the conventional yogurt group (P = 0.05 for GHQ and P = 0.08 for DASS).
DISCUSSION
The consumption of probiotic yogurt or a multispecies probiotic capsule had beneficial effects on mental health parameters in petrochemical workers.
目的
本研究旨在确定补充益生菌酸奶和多菌株益生菌胶囊对石化工人心理健康及下丘脑 - 垂体 - 肾上腺轴的影响。
方法
本随机双盲、安慰剂对照试验共纳入70名石化工人。受试者被随机分为三组，分别接受每日100克益生菌酸奶 + 1粒安慰剂胶囊（n = 25）、每日1粒益生菌胶囊 + 100克常规酸奶（n = 25）或每日100克常规酸奶 + 1粒安慰剂胶囊（n = 20），为期6周。测量心理健康参数，包括一般健康问卷（GHQ）和抑郁焦虑压力量表（DASS）得分。在干预开始时及干预6周后采集空腹血样，以量化下丘脑 - 垂体 - 肾上腺轴功能。
结果
干预6周后，益生菌酸奶组（18.0 ± 1.5 vs. 13.5 ± 1.9，P = 0.007）和益生菌胶囊组（16.9 ± 1.8 vs. 9.8 ± 1.9，P = 0.001）的GHQ有显著改善，益生菌酸奶组（23.3 ± 3.7 vs. 13.0 ± 3.7，P = 0.02）和益生菌胶囊组（18.9 ± 3.2 vs. 9.4 ± 4.0，P = 0.006）的DASS得分也有显著改善。然而，常规酸奶组无显著改善（GHQ，P = 0.05；DASS，P = 0.08）。
讨论
食用益生菌酸奶或多菌株益生菌胶囊对石化工人的心理健康参数有有益影响。
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