Department of Biochemistry and Nutrition, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Ann Nutr Metab. 2012;60(1):62-8. doi: 10.1159/000335468. Epub 2012 Feb 10.
Due to the enhanced oxygen requirement of the mitochondria-rich placenta primarily during the third trimester, pregnancy is associated with elevated levels of oxidative stress. This study was designed to determine the effects of daily consumption of probiotic yogurt on oxidative stress among Iranian pregnant women.
This randomized single-blind controlled clinical trial was performed among 70 pregnant women, singleton primigravida, aged 18-30 in their third trimester. Subjects were randomly assigned to two groups to consume 200 g/day of either conventional yogurt (n = 33) or probiotic yogurt (n = 37) for 9 weeks. Fasting blood samples were taken at baseline and after a 9-week intervention to measure oxidative stress parameters.
Consumption of probiotic yogurt resulted in increased erythrocyte glutathione reductase (GR) levels as compared to the conventional yogurt (p = 0.01). Despite the significant effect of probiotic yogurt consumption on plasma glutathione (67.9 μmol/l, p = 0.01), erythrocyte glutathione peroxidase (163 mmol/min/ml, p = 0.04) and serum 8-oxo-7,8-dihydroguanine levels (-74.3 ng/ml, p = 0.04), no significant differences were found between the two yogurts in terms of their effects on the mentioned parameters.
Consumption of probiotic yogurt among pregnant women resulted in increased levels of erythrocyte GR as compared to the conventional yogurt, but could not affect other indices of oxidative stress.
由于富含线粒体的胎盘在妊娠晚期主要需要增强的氧气需求，因此妊娠与氧化应激水平升高有关。本研究旨在确定每日食用益生菌酸奶对伊朗孕妇氧化应激的影响。
这是一项在 70 名年龄在 18-30 岁的单胎初产妇妊娠晚期的随机单盲对照临床试验。将受试者随机分为两组，每天分别食用 200 克常规酸奶（n = 33）或益生菌酸奶（n = 37），共 9 周。在基线和 9 周干预后采集空腹血样，以测量氧化应激参数。
与常规酸奶相比，益生菌酸奶的摄入导致红细胞谷胱甘肽还原酶（GR）水平升高（p = 0.01）。尽管益生菌酸奶的摄入对血浆谷胱甘肽（67.9 μmol/l，p = 0.01）、红细胞谷胱甘肽过氧化物酶（163 mmol/min/ml，p = 0.04）和血清 8-氧-7,8-二氢鸟嘌呤水平（-74.3 ng/ml，p = 0.04）有显著影响，但两种酸奶在上述参数方面的影响无显著差异。
与常规酸奶相比，孕妇食用益生菌酸奶可使红细胞 GR 水平升高，但不能影响其他氧化应激指标。
