Moodley Amaran, Quinlisk Patricia, Garvey Ann, Kalas Nicholas, Barash Jason R, Khouri Jessica M
MMWR Morb Mortal Wkly Rep. 2015 Apr 17;64(14):400.
In June 2013, a male newborn aged 9 days (delivered after a full-term pregnancy) was brought to a hospital emergency department with a 2-day history of constipation, fussiness, and poor feeding. The mother reported her son's symptoms as excessive crying, reluctance to suck, and difficulty in swallowing milk. Within hours of arrival, the infant became less responsive and "floppy," and was intubated for respiratory failure. Infant botulism was suspected and Botulism Immune Globulin Intravenous (Human) (BIG-IV), licensed for the treatment of infant botulism types A and B, was administered on hospital day 2. Results of preliminary stool studies were reported positive for botulinum toxin type F on hospital day 3. Clostridium baratii type F was subsequently isolated in stool culture.
2013年6月,一名9天大的男婴(足月妊娠后分娩)因便秘、烦躁和喂养困难2天被送至医院急诊科。母亲报告儿子的症状为过度哭闹、不愿吸吮和吞咽牛奶困难。到达医院数小时内,婴儿反应变差且“松软”,因呼吸衰竭行气管插管。怀疑为婴儿肉毒中毒,于住院第2天给予已获许可用于治疗A型和B型婴儿肉毒中毒的静脉注射肉毒中毒免疫球蛋白(人)(BIG-IV)。住院第3天,初步粪便检查结果报告肉毒杆菌毒素F型呈阳性。随后在粪便培养中分离出F型巴氏梭菌。