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比较维达洛芬和酮洛芬术前和术后用于控制犬疼痛。

A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs.

机构信息

Laboratório de Investigação Médica 8, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Av. Doutor Arnaldo, 455, 2° andar, sala 2120, Cerqueira César, 01246-903, São Paulo, SP, Brazil.

Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil.

出版信息

BMC Vet Res. 2015 Feb 7;11:24. doi: 10.1186/s12917-015-0338-4.

DOI:10.1186/s12917-015-0338-4
PMID:25880775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4324799/
Abstract

BACKGROUND

This prospective randomized blinded clinical study aimed to investigate the potential of vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy.

RESULTS

Pain control was effective and rescue analgesia was not necessary in any group. Pain scores were not significantly different between groups. The respiratory rate and rectal temperature were decreased in all groups at extubation until 6 hours post-extubation compared to baseline. Cortisol and epinephrine levels were increased only at 0.5 hours after extubation in all groups compared to baseline.

CONCLUSIONS

Vedaprofen did not present any preventive analgesic effect. Pre- and postoperative vedaprofen were as effective as ketoprofen for postoperative pain control.

摘要

背景

本前瞻性随机双盲临床研究旨在研究 vedaprofen 用于预防镇痛的潜力，将其与术后给予犬行上颌切除术或下颌切除术时的 ketoprofen 的镇痛效果进行比较。

结果

所有组的疼痛控制均有效，无需使用解救性镇痛。各组的疼痛评分无显著差异。与基础值相比，所有组在拔管时的呼吸频率和直肠温度均降低，直至拔管后 6 小时。与基础值相比，所有组仅在拔管后 0.5 小时时皮质醇和肾上腺素水平升高。

结论

vedaprofen 没有表现出任何预防镇痛作用。术前和术后给予 vedaprofen 与术后给予 ketoprofen 一样有效，均可控制术后疼痛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/b770c1073240/12917_2015_338_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/0675fb00c788/12917_2015_338_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/9639908ed664/12917_2015_338_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/36e8b9174672/12917_2015_338_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/b770c1073240/12917_2015_338_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/0675fb00c788/12917_2015_338_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/9639908ed664/12917_2015_338_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/36e8b9174672/12917_2015_338_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1f/4324799/b770c1073240/12917_2015_338_Fig4_HTML.jpg

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本文引用的文献

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Local Reg Anesth. 2014 May 29;7:17-22. doi: 10.2147/LRA.S62160. eCollection 2014.
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Field trials with Vedaprofen, a new non-steroidal anti-inflammatory drug.使用新型非甾体抗炎药维达洛芬进行的田间试验。
Vet Q. 1996 Apr;18(sup1):20. doi: 10.1080/01652176.1996.9694651.
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Clinical efficacy of vedaprofen in dogs suffering from disorders of the misculoskeletal system.维达洛芬对患有肌肉骨骼系统疾病犬类的临床疗效。
Vet Q. 1997 Apr;19(sup1):28-29. doi: 10.1080/01652176.1997.9694793.
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Review article: Preventive analgesia: quo vadimus?综述文章：预防性镇痛：何去何从？
Anesth Analg. 2011 Nov;113(5):1242-53. doi: 10.1213/ANE.0b013e31822c9a59. Epub 2011 Sep 30.
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Am J Vet Res. 2010 Sep;71(9):1019-26. doi: 10.2460/ajvr.71.9.1019.
6
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Reprod Domest Anim. 2010 Dec;45(6):e458-60. doi: 10.1111/j.1439-0531.2009.01572.x.
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Comparison of analgesic efficacy of preoperative or postoperative carprofen with or without preincisional mepivacaine epidural anesthesia in canine pelvic or femoral fracture repair.术前或术后使用卡洛芬联合或不联合切口前甲哌卡因硬膜外麻醉对犬骨盆或股骨骨折修复镇痛效果的比较。
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