Rojer H, Aurich C
Centre for Artificial Insemination and Embryo Transfer, University for Veterinary Sciences, Vienna, Austria.
Reprod Domest Anim. 2010 Dec;45(6):e458-60. doi: 10.1111/j.1439-0531.2009.01572.x.
Recently, successful treatment of mares with a history of persistent mating-induced endometritis (PMIE) with dexamethasone has been reported. As systemic treatment of horses with glucocorticoids should be handled with caution, we tested the hypothesis that treatment with the non-steroid anti-inflammatory drug (NSAID) vedaprofen, an inhibitor of cyclooxygenase-2, may have comparative, positive effects on fertility. Barren mares with a history of repeated PMIE were treated with vedaprofen (n = 8; initially 2 mg/kg bodyweight followed by 1 mg/kg orally twice daily) from 1 day before the first insemination to 1 day after ovulation or left untreated (n = 9). All mares received oxytocin (20 I.E. s.c.) thrice daily. Uterine swabs were collected for bacteriology and cytology. The day after ovulation, fluid accumulation was detected in three control mares and four treated mares (n.s.). The percentage of neutrophils in uterine cytology was significantly increased in comparison to the day before ovulation irrespective of treatment. Pregnancy was confirmed in two of nine mares in the control group and seven of eight mares in the treatment group (p < 0.05). NSAIDs may positively affect fertility in mares with a history of PMIE.
最近，有报道称地塞米松成功治疗了有持续性交配诱发子宫内膜炎（PMIE）病史的母马。由于对马进行糖皮质激素全身治疗应谨慎处理，我们检验了以下假设：使用非甾体抗炎药（NSAID）维达洛芬（一种环氧化酶-2抑制剂）进行治疗可能对生育能力有类似的积极影响。有反复PMIE病史的不育母马，从首次输精前1天至排卵后1天，用维达洛芬治疗（n = 8；初始剂量为2 mg/kg体重，随后口服1 mg/kg，每日两次），或不进行治疗（n = 9）。所有母马每天皮下注射三次催产素（20国际单位）。采集子宫拭子进行细菌学和细胞学检查。排卵后第二天，在3匹对照母马和4匹治疗母马中检测到有积液（无显著差异）。无论治疗与否，与排卵前一天相比，子宫细胞学中性粒细胞百分比均显著增加。对照组9匹母马中有2匹怀孕，治疗组8匹母马中有7匹怀孕（p < 0.05）。非甾体抗炎药可能对有PMIE病史的母马的生育能力有积极影响。
