Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Biostatistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ocul Surf. 2015 Apr;13(2):133-49. doi: 10.1016/j.jtos.2014.12.002. Epub 2015 Feb 18.
The purpose of this review was to systematically analyze publications related to the role of meibomian gland disease in ocular surface inflammation, with special reference to meibomitis as an inflammatory form of meibomian gland dysfunction (MGD). Meibomian gland inflammation is often present with the ocular surface inflammation in conditions such as blepharokeratoconjunctivitis, ocular rosacea, and phlyctenular keratitis, but its contribution is often overlooked, especially in younger subjects. This can result in misdiagnosis, mistreatment, and, sometimes, severe visual impairment. We identified a related disease entity, seen predominantly in young patients, of ocular surface inflammation associated with meibomitis, which we termed meibomitis-related keratoconjunctivitis. Its specific clinical features are similar to those observed in the above-mentioned diseases, and the inflammatory form of MGD was found to be closely involved in the ocular surface inflammation seen in those four diseases, based on our statistical evaluation. The diagnosis and management of meibomitis, an inflammatory form of MGD, is vital for the successful treatment of the induced ocular surface inflammation. We propose that the ocular surface and the adnexal meibomian glands should be considered as one unit, i.e., the "meibomian gland and ocular surface" (MOS), when encountered in the clinical setting.
本综述旨在系统分析与睑板腺疾病在眼表炎症中的作用相关的出版物，特别参考睑板炎作为睑板腺功能障碍（MGD）的炎症形式。在诸如睑缘炎-角结膜炎、眼红斑痤疮和滤泡性角结膜炎等疾病中，睑板腺炎症通常与眼表炎症同时存在，但它的作用往往被忽视，尤其是在年轻患者中。这可能导致误诊、误治，有时甚至导致严重的视力损害。我们确定了一种相关的疾病实体，主要见于年轻患者，即与睑板炎相关的眼表炎症，我们称之为睑板炎相关性角结膜炎。根据我们的统计评估，其特定的临床特征与上述疾病相似，并且发现 MGD 的炎症形式与这四种疾病中所见的眼表炎症密切相关。MGD 的炎症形式的诊断和管理对于成功治疗诱导的眼表炎症至关重要。我们建议，在临床环境中，当遇到眼附属器的睑板腺和眼表时，应将其视为一个单元，即“睑板腺和眼表”（MOS）。
