共生细菌和病原体在眼部疾病中的双重作用
Dual Role of : Commensal Bacterium and Pathogen in Ocular Diseases.
作者信息
Suzuki Tomo, Kinoshita Shigeru
机构信息
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
Department of Ophthalmology, Kyoto City Hospital Organization, Kyoto 604-8845, Japan.
出版信息
Microorganisms. 2024 Aug 12;12(8):1649. doi: 10.3390/microorganisms12081649.
Microbiota present around the ocular surface, encompassing the eyelid skin, the conjunctival sac, and the meibomian glands, play a significant role in various inflammatory conditions associated with the ocular surface. (), formerly, , is one of the most predominant commensal bacteria and its relative abundance declines with aging. However, it can act as both an infectious and an immunogenic pathogen. As an infectious pathogen, has been reported to cause late onset endophthalmitis post-cataract surgery and infectious keratitis. On the other hand, it can trigger immune responses resulting in conditions such as phlyctenules in the cornea, chalazion in the meibomian glands, and granuloma formation in ocular sarcoidosis. This review explores the role of in ocular inflammation, specifically highlighting its implications for diagnosis and management.
存在于眼表周围的微生物群，包括眼睑皮肤、结膜囊和睑板腺，在与眼表相关的各种炎症性疾病中发挥着重要作用。（），以前称为，是最主要的共生细菌之一，其相对丰度随年龄增长而下降。然而，它既可以作为感染性病原体，也可以作为免疫原性病原体。作为一种感染性病原体，据报道它可导致白内障手术后迟发性眼内炎和感染性角膜炎。另一方面，它可引发免疫反应，导致诸如角膜泡性结膜炎、睑板腺霰粒肿和眼部结节病中的肉芽肿形成等病症。本综述探讨了（）在眼部炎症中的作用，特别强调了其对诊断和治疗的影响。
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