Takemori K, Mikami S, Nihira S, Sasaki N
Department of Hygiene, Hirosaki University School of Medicine, Japan.
Tohoku J Exp Med. 1989 Aug;158(4):269-81. doi: 10.1620/tjem.158.269.
The cross-sectional association of blood pressure with urinary sodium and potassium excretion was investigated with a stepwise regression analysis. Spot urine of 7441 females between 40 and 69 years was collected from 169 municipalities (88 urban and 81 rural) covering all prefectures in Japan. The filter paper sampling technique for urine was used to collect samples of subjects from March to December in 1985. Spot urine samples were analyzed for sodium, potassium and creatinine. In addition, 24-hr sodium and potassium excretions were estimated by predictive equations. Blood pressure, sodium excretion and sodium potassium ratios were higher in rural areas than in urban areas. Consistent positive correlations between urinary sodium and blood pressure, and negative correlations between urinary potassium and blood pressure were observed in the whole country of Japan, in both urban and rural areas, and also in separate observations of twelve regions in Japan with some exceptions. When compared in standardized partial regression coefficients, relative effects of potassium on systolic blood pressure were higher than those of sodium in the whole of Japan, in urban and rural areas, and in five among the twelve regions. The present Japanese study confirmed a positive within-population relationship between sodium excretion and blood pressure and a negative relationship between potassium excretion and blood pressure.
采用逐步回归分析研究血压与尿钠和钾排泄的横断面关联。从覆盖日本所有县的169个市（88个城市和81个农村）收集了7441名40至69岁女性的即时尿样。1985年3月至12月，采用滤纸片尿液采样技术收集受试者样本。对即时尿样进行钠、钾和肌酐分析。此外，通过预测方程估算24小时钠和钾排泄量。农村地区的血压、钠排泄量和钠钾比高于城市地区。在日本全国、城市和农村地区，以及对日本12个地区的单独观察中，除了一些例外情况，均观察到尿钠与血压之间呈一致的正相关，尿钾与血压之间呈负相关。在标准化偏回归系数的比较中，在日本全国、城市和农村地区以及12个地区中的5个地区，钾对收缩压的相对影响高于钠。日本目前的这项研究证实了人群中钠排泄与血压之间呈正相关，钾排泄与血压之间呈负相关。
