2010 - 2012年韩国国家健康与营养检查调查V中高血压和血压正常人群的脉压与体重指数之间的关联
Association between pulse pressure and body mass index in hypertensive and normotensive populations in the Korea National Health and Nutrition Examination Survey V, 2010-2012.
作者信息
Kang Min Gyu, Kim Kye-Hwan, Koh Jin-Sin, Park Jeong Rang, Hwang Seok-Jae, Hwang Jin-Yong, Ahn Jong Hwa, Jang Jeong Yoon, Jeong Young-Hoon, Kwak Choong Hwan, Park Hyun Woong
机构信息
Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Korea.
Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Korea.
出版信息
J Clin Hypertens (Greenwich). 2017 Apr;19(4):395-401. doi: 10.1111/jch.12935. Epub 2016 Nov 2.
The authors conducted a national cross-sectional cohort study to evaluate the associations between pulse pressure (PP) and body mass index (BMI) and sex, according to blood pressure (BP) status. A total of 18 812 patients without a history of antihypertensive medication and cardiovascular disease were selected. There was good concordance between PP and the selected cardiovascular risk factors. PP increased with high BMI among patients with normal BP, but decreased with high BMI among patients with hypertension (HTN). BMI (ß, -0.260; SE, 0.039 [P<.001]) and male sex (ß, -4.727; SE, 1.100 [P<.001]) were negatively correlated with PP in a multivariate model adjusted for several risk factors in patients with HTN. In conclusion, PP was negatively correlated with BMI in patients with HTN, which may explain the higher cardiovascular risk in lean persons and women with HTN.
作者开展了一项全国性横断面队列研究，以根据血压（BP）状况评估脉压（PP）与体重指数（BMI）及性别的关联。共选取了18812例无抗高血压药物治疗史和心血管疾病史的患者。PP与所选心血管危险因素之间存在良好的一致性。在血压正常的患者中，PP随高BMI而升高，但在高血压（HTN）患者中，PP随高BMI而降低。在针对HTN患者的多个危险因素进行校正的多变量模型中，BMI（β，-0.260；标准误，0.039 [P<0.001]）和男性（β，-4.727；标准误，1.100 [P<0.001]）与PP呈负相关。总之，HTN患者的PP与BMI呈负相关，这可能解释了瘦型HTN患者和女性心血管风险较高的原因。
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