Friedrich T, Durante M, Scholz M
Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany
Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany Institut für Festkörperphysik, Technische Universität Darmstadt, Darmstadt, Germany.
Radiat Prot Dosimetry. 2015 Sep;166(1-4):61-5. doi: 10.1093/rpd/ncv147. Epub 2015 Apr 16.
A simulation approach for the calculation of the LET-dependent yield of double-strand breaks (DSB) is presented. The model considers DSB formed as two close-lying single-strand breaks (SSB), whose formation is mediated by both intra-track processes (single electrons) or at local doses larger than about 1000 Gy in particle tracks also by electron inter-track processes (two independent electron tracks). A Monte Carlo algorithm and an analytical formula for the DSB yield are presented. The approach predicts that the DSB yield is enhanced after charged particle irradiation of high LET compared with X-ray or gamma radiation. It is used as an inherent part of the local effect model, which is applied to estimate the relative biological effectiveness of high LET radiation.
本文提出了一种用于计算与传能线密度（LET）相关的双链断裂（DSB）产额的模拟方法。该模型认为DSB是由两个紧密相邻的单链断裂（SSB）形成的，其形成由径迹内过程（单个电子）介导，或者在粒子径迹中局部剂量大于约1000 Gy时，也由电子径迹间过程（两个独立的电子径迹）介导。给出了DSB产额的蒙特卡罗算法和解析公式。该方法预测，与X射线或γ射线相比，高LET带电粒子辐照后DSB产额会增加。它被用作局部效应模型的一个固有部分，该模型用于估计高LET辐射的相对生物效能。
