[酒精对大鼠器官中天冬氨酸氨基转移酶活性日变化的影响]
[The effect of alcohols on daily variations in aspartate amino- transferase activity in rat organs].
作者信息
Korkach V I, Spitkovskaia L D, Kul'chitskaia Iu G
出版信息
Ukr Biokhim Zh (1978). 1989 Sep-Oct;61(5):102-6.
The 7 day-long intragastric administration of ethanol and ethyleneglycol in a dose of 1/3 DL50 was studied for its effect on the circadian variations of the aspartate aminotransferase activity (AST, EC 2.6, 1.1) in the liver, brain, myocardium and kidney of male rats. The ethanol and ethylene glycol administration reduced the mean circadian enzymic activity in the above organs. Moreover, ethanol significantly reduced the amplitude of circadian variations of the AST activity in the liver, brain and kidney, while ethylene glycol--in the liver, myocardium and kidney.
研究了以1/3半数致死剂量连续7天胃内给予乙醇和乙二醇对雄性大鼠肝脏、脑、心肌和肾脏中天冬氨酸转氨酶活性（AST，EC 2.6, 1.1）昼夜变化的影响。给予乙醇和乙二醇降低了上述器官中酶的平均昼夜活性。此外，乙醇显著降低了肝脏、脑和肾脏中AST活性的昼夜变化幅度，而乙二醇降低了肝脏、心肌和肾脏中AST活性的昼夜变化幅度。
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