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Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges.

作者信息

Huang Yue-Wern, Lee Han-Jung, Tolliver Larry M, Aronstam Robert S

机构信息

Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409-1120, USA.

Department of Natural Resources and Environmental Studies, National Dong Hwa University, Hualien 97401, Taiwan.

出版信息

Biomed Res Int. 2015;2015:834079. doi: 10.1155/2015/834079. Epub 2015 Mar 26.

DOI:10.1155/2015/834079
PMID:25883975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4391616/
Abstract

Many viral and nonviral systems have been developed to aid delivery of biologically active molecules into cells. Among these, cell-penetrating peptides (CPPs) have received increasing attention in the past two decades for biomedical applications. In this review, we focus on opportunities and challenges associated with CPP delivery of nucleic acids and nanomaterials. We first describe the nature of versatile CPPs and their interactions with various types of cargoes. We then discuss in vivo and in vitro delivery of nucleic acids and nanomaterials by CPPs. Studies on the mechanisms of cellular entry and limitations in the methods used are detailed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/85b525ed8275/BMRI2015-834079.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/a07b4bdd1c74/BMRI2015-834079.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/92e46bcf3ec2/BMRI2015-834079.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/1221182e5a8b/BMRI2015-834079.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/48e3bea6f491/BMRI2015-834079.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/c3b98f3cb3e0/BMRI2015-834079.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/6c94e7bde6ce/BMRI2015-834079.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/85b525ed8275/BMRI2015-834079.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/a07b4bdd1c74/BMRI2015-834079.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/92e46bcf3ec2/BMRI2015-834079.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/1221182e5a8b/BMRI2015-834079.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/48e3bea6f491/BMRI2015-834079.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/c3b98f3cb3e0/BMRI2015-834079.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/6c94e7bde6ce/BMRI2015-834079.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4391616/85b525ed8275/BMRI2015-834079.007.jpg

相似文献

[1]
Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges.

Biomed Res Int. 2015

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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Adv Drug Deliv Rev. 2016-6-25

[10]
[The development of cell-penetrating peptides in drug delivery system].

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引用本文的文献

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[2]
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[3]
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Int J Mol Sci. 2023-11-23

[4]
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Pharmaceutics. 2023-7-7

[5]
Advancement and application of novel cell-penetrating peptide in cancer management.

3 Biotech. 2023-7

[6]
Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency.

Pharmaceutics. 2023-1-14

[7]
Recent Developments and Strategies for the Application of -Mediated Transformation of Apple × Borkh.

Front Plant Sci. 2022-6-30

[8]
The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells.

Pharmaceutics. 2022-6-15

[9]
Translocating Peptides of Biomedical Interest Obtained from the Spike (S) Glycoprotein of the SARS-CoV-2.

Membranes (Basel). 2022-6-10

[10]
The Progress and Promise of RNA Medicine─An Arsenal of Targeted Treatments.

J Med Chem. 2022-5-26

本文引用的文献

[1]
Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity.

Pharmaceuticals (Basel). 2009-9-25

[2]
Cellular delivery of noncovalently-associated macromolecules by cell-penetrating peptides.

Curr Pharm Biotechnol. 2014

[3]
Rational design of a series of novel amphipathic cell-penetrating peptides.

Int J Pharm. 2014-1-22

[4]
Applications of cell-penetrating peptides for tumor targeting and future cancer therapies.

Pharmaceuticals (Basel). 2012-9-12

[5]
Delivery materials for siRNA therapeutics.

Nat Mater. 2013-11

[6]
Rational design of a biomimetic cell penetrating peptide library.

ACS Nano. 2013-9-30

[7]
Cell-penetrating peptides: achievements and challenges in application for cancer treatment.

J Biomed Mater Res A. 2013-7-30

[8]
Endocytic Trafficking of Nanoparticles Delivered by Cell-penetrating Peptides Comprised of Nona-arginine and a Penetration Accelerating Sequence.

PLoS One. 2013-6-26

[9]
Synthesis, characterization and applications of carboxylated and polyethylene-glycolated bifunctionalized InP/ZnS quantum dots in cellular internalization mediated by cell-penetrating peptides.

Colloids Surf B Biointerfaces. 2013-6-2

[10]
Intracellular delivery of nanoparticles and DNAs by IR9 cell-penetrating peptides.

PLoS One. 2013-5-28

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