Fan Bo, Jin Ming-ji, Huang Wei, Wang Qi-ming, Gao Zhong-gao
Yao Xue Xue Bao. 2016 Feb;51(2):264-71.
Cell membrane serves as the natural barrier. Cell-penetrating peptides(CPPs) have been a powerful vehicle for the intracellular delivery of a large variety of cargoes cross the cell membrane. The efficiency of intracellular delivery of drugs, proteins, peptides and nucleic acid, as well as various nanoparticulate pharmaceutical carriers(e.g., liposomes, polymeric micelles and inorganic nanoparticles) has been demonstrated both in vitro and in vivo. This review focuses on the CPPs-based strategy for intracellular delivery of small molecule drugs, proteins, peptides, nucleic acid and CPP-modified nanocarriers.
细胞膜是天然屏障。细胞穿透肽（CPPs）是一种强大的载体，可使多种物质穿过细胞膜并递送至细胞内。药物、蛋白质、肽、核酸以及各种纳米颗粒药物载体（如脂质体、聚合物胶束和无机纳米颗粒）的细胞内递送效率已在体外和体内得到证实。本文综述了基于细胞穿透肽的策略在小分子药物、蛋白质、肽、核酸以及细胞穿透肽修饰的纳米载体细胞内递送方面的应用。
