结直肠癌中过表达的白细胞介素-32失调会诱导转移。
Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis.
作者信息
Yang Yi, Wang Zihao, Zhou Yiming, Wang Xiaoxiao, Xiang Jianbin, Chen Zongyou
机构信息
Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Floor 16, Building 2, 12 Wulumuqizhong Road, Shanghai, 200040, China.
出版信息
World J Surg Oncol. 2015 Apr 12;13:146. doi: 10.1186/s12957-015-0552-3.
BACKGROUND
Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.
METHODS
Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed.
RESULTS
The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).
CONCLUSIONS
The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.
背景
白细胞介素（IL）-32是一种已被描述的细胞内多能促炎介质，其特征在于核因子κB（NF-κB）和信号转导与转录激活因子3（STAT3）的信号传导。
方法
我们的研究调查了IL-32表达在结直肠癌（CRC）转移中是否具有临床意义。共纳入70例CRC患者，其中47例为单一CRC器官转移病灶，其余为原发性CRC病灶（T4NxM0）。采用免疫组织化学法检测IL-32表达，并分析IL-32表达与CRC转移之间的相关性。
结果
CRC器官转移组中IL-32的阳性率高于原发性CRC组（P<0.05）。有淋巴结转移的原发性CRC中IL-32的阳性率高于无淋巴结转移的原发性CRC中IL-32的阳性率（P<0.05）。
结论
IL-32表达水平可影响CRC的N分级。因此，IL-32表达可能促进CRC的器官转移和淋巴结转移。
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