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微小 RNA-29b-3p 通过 IL32/AKT 信号通路抑制口腔鳞状细胞癌细胞迁移和侵袭。

MicroRNA-29b-3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway.

机构信息

Department of Prosthodontics, College of Stomatology, Dalian Medical University, Dalian, China.

Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

出版信息

J Cell Mol Med. 2020 Jan;24(1):841-849. doi: 10.1111/jcmm.14794. Epub 2019 Nov 3.

DOI:10.1111/jcmm.14794
PMID:31680452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6933408/
Abstract

Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR-29b-3p as a guarder that suppressed migration and invasion of OSCC cells and was down-regulated in the most invasive cells. Besides that, the invasion suppression role of miR-29b-3p was achieved through the IL32/AKT pathway. Thus, miR-29b-3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC.

摘要

口腔鳞状细胞癌 (OSCC) 侵袭性强，预后不良。我们之前通过微流控技术分离出最具侵袭性的细胞，这些细胞类似于侵袭性肿瘤前沿，并在之前的工作中探索了它们差异表达的 microRNAs（miRNAs）。在这里，我们验证了 miR-29b-3p 作为一种守护者，抑制 OSCC 细胞的迁移和侵袭，并且在最具侵袭性的细胞中下调。此外，miR-29b-3p 的侵袭抑制作用是通过 IL32/AKT 通路实现的。因此，miR-29b-3p 和 IL32 可能作为治疗靶点，用于阻断 OSCC 的进展并改善其预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/d618cf8de076/JCMM-24-841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/4ece440bdfb7/JCMM-24-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/6bc307aeed64/JCMM-24-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/325af5a0ab15/JCMM-24-841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/0646be78512b/JCMM-24-841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/e08b3676ba16/JCMM-24-841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/d618cf8de076/JCMM-24-841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/4ece440bdfb7/JCMM-24-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/6bc307aeed64/JCMM-24-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/325af5a0ab15/JCMM-24-841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/0646be78512b/JCMM-24-841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/e08b3676ba16/JCMM-24-841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46da/6933408/d618cf8de076/JCMM-24-841-g006.jpg

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