Tiihonen Kirsti, Rautonen Nina, Alhoniemi Esa, Ahotupa Markku, Stowell Julian, Vasankari Tommi
DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, FI-02460, Kantvik, Finland.
Danisco Health and Nutrition, Kantvik, Finland.
Nutr J. 2015 Mar 8;14:23. doi: 10.1186/s12937-015-0009-0.
Three independent trials were conducted to evaluate postprandial triglyceride (TG) responses in subjects with different lipid metabolism. The effect of polydextrose (PDX), a soluble non-digestible carbohydrate, on postprandial response was also studied using practically relevant, high fat meal interventions.
A total of 19 normolipidemic (average BMI 24.1 kg/m(2)), 21 overweight/hyperlipidemic (average BMI 29.6 kg/m(2)) and 18 obese/non-diabetic subjects (average BMI 33.6 kg/m(2)) were included in the study. On two separate occasions all subjects ate two high-fat meals (4293 kJ, 36% from fat), one with PDX (either 12.5 g or 15 g) and one without PDX during placebo-controlled, double-blind, crossover and randomized trials. To obtain the triglyceride measurements venous blood samples were taken before the consumption of the test meal and five times afterwards, up to 6 h post-test meal. The triglyceride responses were modeled using a mixed-effects linear model.
The key variables that explain the variation of the postprandial triglyceride response in the different subject groups were: baseline triglyceride concentration, time point, and PDX vs. placebo treatment (p < 0.05). The maximum postprandial TG concentration was more pronounced in hyperlipidemic group compared to normolipidemic (p < 0.001) or obese groups (p < 0.01). The modeled TG response analysis showed that irrespective of the study population PDX supplementation was one of the factors significantly reducing triglyceride response compared to the placebo treatment (p < 0.05).
Subjects with elevated fasting triglyceride levels display exaggerated and prolonged postprandial triglyceride responses. PDX, a soluble non-digestible carbohydrate, may offer a dietary concept for reducing the postprandial triglyceride response after the consumption of a meal containing a high concentration of fat.
开展了三项独立试验，以评估不同脂质代谢受试者的餐后甘油三酯（TG）反应。还采用实际相关的高脂肪餐干预措施，研究了可溶性非消化性碳水化合物聚葡萄糖（PDX）对餐后反应的影响。
本研究共纳入19名血脂正常者（平均BMI 24.1kg/m²）、21名超重/高脂血症患者（平均BMI 29.6kg/m²）和18名肥胖/非糖尿病受试者（平均BMI 33.6kg/m²）。在安慰剂对照、双盲、交叉和随机试验中，所有受试者在两个不同的场合分别食用两顿高脂肪餐（4293千焦，36%来自脂肪），一顿含有PDX（12.5克或15克），另一顿在服用安慰剂期间不含PDX。为了测量甘油三酯，在食用试验餐之前和之后五次采集静脉血样，直至试验餐后6小时。使用混合效应线性模型对甘油三酯反应进行建模。
解释不同受试者组餐后甘油三酯反应变化的关键变量为：基线甘油三酯浓度、时间点以及PDX与安慰剂治疗（p<0.05）。与血脂正常组（p<0.001）或肥胖组（p<0.01）相比，高脂血症组餐后TG浓度峰值更为明显。建模的TG反应分析表明，无论研究人群如何，与安慰剂治疗相比，补充PDX是显著降低甘油三酯反应的因素之一（p<0.05）。
空腹甘油三酯水平升高的受试者餐后甘油三酯反应会过度且持续时间延长。可溶性非消化性碳水化合物PDX可能为减少食用高脂肪餐餐后的甘油三酯反应提供一种饮食理念。
