Narama I, Kino I
Department of Pathology, Hamamatsu University School of Medicine, Japan.
Acta Neuropathol. 1989;79(1):52-60. doi: 10.1007/BF00308958.
The morphology and function of peripheral motor nerves of WBN/Kob rats of the newly identified strain with late onset and long-lasting diabetes were studied in comparison with those of nondiabetic age-matched rats. The most conspicuous and frequent change seen by electron microscopy in the diabetic rats was myelinopathy, initiated by vesicle formation in granular material accumulated in the myelin lamella. Initial changes developed into myelin blebbing or distention, demyelination and remyelination. A decreased population of nerve fibers in diabetic rats of advanced age suggested that the final stage of these changes was neuronal loss resulting from complete destruction of the neurons. The myelinopathy was consistently more frequent and conspicuous in diabetic rats than in age-matched nondiabetic rats, but the difference was not significant in rats of over 28 months old, because of the age-dependent increase of the change in older rats. The conduction velocity was significantly less in diabetic rats than in age-matched nondiabetic animals at 20 months but not at 28 months of age, because at the older age nondiabetic rats also showed a reduced conduction velocity. These findings showed that male WBN/Kob rats develop diabetic motor neuropathy, but that the essential changes in diabetic neuropathy are indistinguishable morphologically and functionally from those in age-dependent neuropathy.
将新鉴定的具有迟发性和持续性糖尿病的WBN/Kob大鼠的外周运动神经的形态和功能与年龄匹配的非糖尿病大鼠进行了比较研究。在糖尿病大鼠中，通过电子显微镜观察到的最明显和最常见的变化是髓鞘病，其始于髓鞘板层中积累的颗粒物质中的小泡形成。最初的变化发展为髓鞘肿胀或扩张、脱髓鞘和再髓鞘化。老年糖尿病大鼠神经纤维数量减少表明，这些变化的最终阶段是神经元因完全破坏而丧失。糖尿病大鼠的髓鞘病始终比年龄匹配的非糖尿病大鼠更频繁、更明显，但在28个月以上的大鼠中差异不显著，因为老年大鼠中这种变化随年龄增长而增加。在20个月时，糖尿病大鼠的传导速度明显低于年龄匹配的非糖尿病动物，但在28个月时则不然，因为在老年时非糖尿病大鼠的传导速度也降低。这些发现表明，雄性WBN/Kob大鼠会发生糖尿病性运动神经病，但糖尿病性神经病的本质变化在形态和功能上与年龄相关性神经病无法区分。
