Moore S A, Peterson R G, Felten D L, O'Connor B L
Brain Res Bull. 1982 Mar;8(3):317-23. doi: 10.1016/0361-9230(82)90065-x.
Electron microscopic examination of tibial nerves from streptozotocin-diabetic, alloxan-diabetic and age-matched control rats was undertaken at two weeks and two, four, eight, and twelve months following the induction of diabetes. Many myelinated axons of both diabetic and control rats contained glycogen-like granules, axon-Schwann cell networks and fingerlike intrusions of myelin. These axonal changes were observed more frequently with advancing age and duration of diabetes, suggesting that they are related to aging or repeated injury. A larger proportion of diabetic axons than control axons were affected at early time periods, but by eight and twelve months the control axons were as frequently (or more frequently) involved as diabetic axons. Thus, experimental diabetes may confer upon peripheral myelinated axons an increased susceptability to aging or repeated injury. Specific morphologic abnormalities in peripheral myelinated axons associated uniquely with streptozotocin or alloxan diabetes in the rat were not noted.
在糖尿病诱导后的两周以及两、四、八和十二个月，对链脲佐菌素诱导糖尿病、四氧嘧啶诱导糖尿病以及年龄匹配的对照大鼠的胫神经进行了电子显微镜检查。糖尿病大鼠和对照大鼠的许多有髓轴突都含有糖原样颗粒、轴突-施万细胞网络以及髓鞘的指状侵入。随着年龄增长和糖尿病病程延长，这些轴突变化更频繁地被观察到，这表明它们与衰老或反复损伤有关。在早期，受影响的糖尿病轴突比例高于对照轴突，但到八个月和十二个月时，对照轴突与糖尿病轴突受累的频率相同（或更高）。因此，实验性糖尿病可能使外周有髓轴突对衰老或反复损伤的易感性增加。未发现大鼠外周有髓轴突中与链脲佐菌素或四氧嘧啶糖尿病独特相关的特定形态学异常。
