Sun Yi-Peng, Cai Yuan-Yuan, Li Hong-Miao, Deng Sen-Miao, Leng Rui-Xue, Pan Hai-Feng
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Faculty of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
J Diabetes Complications. 2015 Jul;29(5):724-30. doi: 10.1016/j.jdiacomp.2015.03.018. Epub 2015 Apr 6.
To derive a more precise estimation of carotid intima-media thickness (CIMT) levels in patients with type 1 diabetes mellitus (T1DM) by meta-analysis.
PubMed and Embase databases were searched to identify all available studies comparing CIMT levels between T1DM group and control group. Meta-analysis was performed to compare the difference of overall mean CIMT levels between the two groups. Publication bias was evaluated by funnel plot, Begg' test and Egger' test. Meta-regression analysis was conducted to investigate the influential factors on CIMT difference. The meta-analysis was conducted by STATA 12.0 software.
A total of 1840 articles were obtained after searching databases; 47 studies were finally included in the meta-analysis. Significant heterogeneity was observed among these studies (Q = 768.75, P < 0.001, I(2) = 94.0%). Compared with the control group, the T1DM group had significantly higher CIMT levels (standardized mean difference: 1.01, 95% CI: 0.75-1.28; P < 0.001). A likely source of heterogeneity was Newcastle-Ottawa Scale (NOS) scores and sample size ratio of patents and controls. The funnel plot did not show a skewed or asymmetrical shape, and the result of Begg' test and Egger' test was P = 0.178 and P = 0.145 respectively. Accordingly, it could be assumed that publication bias was not present.
T1DM patients have significantly increased CIMT levels compared to control subjects.
通过荟萃分析得出1型糖尿病（T1DM）患者颈动脉内膜中层厚度（CIMT）水平更精确的估计值。
检索PubMed和Embase数据库，以确定所有比较T1DM组和对照组CIMT水平的现有研究。进行荟萃分析以比较两组总体平均CIMT水平的差异。通过漏斗图、Begg检验和Egger检验评估发表偏倚。进行Meta回归分析以研究影响CIMT差异的因素。使用STATA 12.0软件进行荟萃分析。
检索数据库后共获得1840篇文章；最终47项研究纳入荟萃分析。这些研究之间观察到显著的异质性（Q = 768.75，P < 0.001，I² = 94.0%）。与对照组相比，T1DM组的CIMT水平显著更高（标准化平均差：1.01，95%CI：0.75 - 1.28；P < 0.001）。异质性的一个可能来源是纽卡斯尔-渥太华量表（NOS）评分以及患者与对照的样本量比。漏斗图未显示出偏态或不对称形状，Begg检验和Egger检验的结果分别为P = 0.178和P = 0.145。因此，可以假定不存在发表偏倚。
与对照受试者相比，T1DM患者的CIMT水平显著升高。
