Wu Guangliang, Cai Haiyan, Cai Haobin, Chen Zhao, Tan Lei, Qi Huitao, Cai Yefeng
Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangxi University of Chinese Medicine, Nanning, China.
J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1577-90. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.029. Epub 2015 Apr 15.
Several investigations have been performed to examine the influence of the β-fibrinogen (FGβ) gene polymorphisms on the risk of ischemic stroke, but the results of these studies are controversial. Our study aimed at investigating whether the FGβ gene (-148 C/T, 448 G/A, and -854 G/A) polymorphisms were associated with susceptibility to ischemic stroke by conducting meta-analysis.
Relevant studies were identified from 4 Chinese databases, PUBMED and EMBASE before May 30, 2014. The strength of association was evaluated by the odds ratio with 95% confidence interval. Inconsistency index and the Cochran's Q statistic were used to check heterogeneity. Publication bias was tested using funnel plots and Egger's regression test.
Thirty-two independent studies with 4311 cases and 4124 controls were included. Significant association between -148 C/T polymorphism and the risk of ischemic stroke was found in overall analysis and middle-age, but not in young adults and elderly people. Similarly, association was also observed for -854 G/A polymorphism, especially in cerebral arterial main trunk infarction (MCI) and cerebral penetrating arterial infarction (PCI). However, no significance was found between 448 G/A polymorphism and ischemic stroke in Chinese people; likewise, no evidence of a significant association was observed when stratified according to the subtype of ischemic stroke (MCI and PCI).
These results suggest that -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke.
已有多项研究探讨β-纤维蛋白原（FGβ）基因多态性对缺血性卒中风险的影响，但这些研究结果存在争议。我们的研究旨在通过荟萃分析调查FGβ基因（-148 C/T、448 G/A和-854 G/A）多态性是否与缺血性卒中易感性相关。
在2014年5月30日前从4个中文数据库、PubMed和EMBASE中检索相关研究。采用比值比及95%置信区间评估关联强度。用不一致指数和Cochran's Q统计量检验异质性。采用漏斗图和Egger回归检验检测发表偏倚。
纳入32项独立研究，共4311例病例和4124例对照。总体分析及中年人群中发现-148 C/T多态性与缺血性卒中风险存在显著关联，但在年轻人和老年人中未发现。同样，-854 G/A多态性也存在关联，尤其是在大脑动脉主干梗死（MCI）和大脑穿通动脉梗死（PCI）中。然而，在中国人群中448 G/A多态性与缺血性卒中之间未发现显著关联；同样，根据缺血性卒中亚型（MCI和PCI）分层时也未观察到显著关联的证据。
这些结果表明-148 C/T和-854 G/A多态性可能与缺血性卒中易感性有关。
