Wu Guangliang, Cai Haiyan, Cai Haobin, Chen Zhao, Tan Lei, Qin Xiurong, Cai Yefeng
Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Ruikang Hospital Affiliated of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
J Stroke Cerebrovasc Dis. 2016 Sep;25(9):2126-35. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.001. Epub 2016 Jun 27.
Many studies have investigated the association between the cyclooxygenase-2 (COX-2) gene polymorphism and ischemic stroke. However, results of these studies still remain controversial. To better explain the association between COX-2 polymorphisms (-765G/C and -1195G/A) and ischemic stroke risk, a meta-analysis was performed.
Relevant studies were identified from 4 Chinese databases (Chinese Biological Medical Literature database, Chinese National Knowledge Infrastructure database, Chongqing VIP database, and Chinese WANFANG database), PUBMED and EMBASE prior to December 2015. The strength of association between COX-2 polymorphism and ischemic stroke was evaluated by the odds ratio (OR) with 95% confidence interval (CI). Inconsistency index (I(2)) and the Cochran's Q statistic were used to check heterogeneity. Publication bias was evaluated by funnel plots and Egger's regression test.
A total of 4086 ischemic stroke cases and 4747 controls were identified. Significant association between COX-2 -765G/C polymorphism and the risk of ischemic stroke was found in Brazilians and the African-Americans. The OR of (CC+GC versus GG) for the Brazilians and African-Americans were (6.328, 95% CI = 2.295-17.448) and (1.644, 95% CI = 1.060-2.551). In addition, the recessive model of the Brazilians gave an OR of 3.621 (95% CI: 1.519-8.630). Furthermore, the (GC versus GG) and the allele model of the African-Americans were (OR: 1.615, 95% CI = 1.015-2.572) and (OR: 1.422, 95% CI = 1.033-1.957). Significant association was also observed for COX-2 -1195G/A polymorphism in the subtypes of small vessel disease (SVD) of ischemic stroke.
Our study suggests that COX-2 -765G/C and -1195G/A polymorphisms may contribute to susceptibility of ischemic stroke, specifically in Brazilians and the African-Americans, and those of SVD.
许多研究探讨了环氧化酶-2（COX-2）基因多态性与缺血性卒中之间的关联。然而，这些研究的结果仍存在争议。为了更好地解释COX-2基因多态性（-765G/C和-1195G/A）与缺血性卒中风险之间的关联，我们进行了一项荟萃分析。
在2015年12月之前，从4个中文数据库（中国生物医学文献数据库、中国知网数据库、维普数据库和万方数据库）、PUBMED和EMBASE中检索相关研究。通过比值比（OR）及95%置信区间（CI）评估COX-2基因多态性与缺血性卒中之间的关联强度。采用不一致指数（I²）和Cochran's Q统计量检验异质性。通过漏斗图和Egger回归检验评估发表偏倚。
共纳入4086例缺血性卒中病例和4747例对照。在巴西人和非裔美国人中发现COX-2 -765G/C基因多态性与缺血性卒中风险存在显著关联。巴西人和非裔美国人中（CC+GC对比GG）的OR分别为（6.328，95%CI = 2.295 - 17.448）和（1.644，95%CI = 1.060 - 2.551）。此外，巴西人的隐性模型得出的OR为3.621（95%CI：1.519 - 8.630）。此外，非裔美国人中（GC对比GG）及等位基因模型的OR分别为（OR：1.615，95%CI = 1.015 - 2.572）和（OR：1.422，95%CI =
