Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
J Int Med Res. 2020 Feb;48(2):300060520902578. doi: 10.1177/0300060520902578.
Several investigations have shown that the level of fibrinogen (Fg) is associated with the susceptibility to dementia and is usually affected by polymorphisms in its gene. Our study aimed to investigate the relationship between Fg level and the fibrinogen β () −148C/T gene polymorphism in patients with Alzheimer’s disease (AD) and vascular dementia (VaD).
The study included 64 AD patients, 72 VaD patients, and 56 healthy controls (HC). Plasma Fg level was detected by turbidimetry. Among the participants, 64 AD patients, 52 VaD patients, and 56 HC underwent −148C/T polymorphism analysis using restriction fragment length polymorphism-PCR.
Plasma Fg was significantly higher in AD and VaD groups than in HC. The AD and VaD patients with −148 TT genotype had significantly higher plasma Fg than those with CC or CT genotypes. The distribution of CC and CT+TT genotypes differed in the three groups, with the frequency of CT+TT genotypes being higher in AD patients than in the HC group.
Plasma Fg level was significantly correlated with AD and VaD and related to the −148C/T polymorphism of . The TT+CT genotypes and the distribution frequency of the T allele may be related to AD.
多项研究表明，纤维蛋白原（Fg）水平与痴呆易感性有关，且通常受其基因多态性影响。本研究旨在探讨阿尔茨海默病（AD）和血管性痴呆（VaD）患者纤维蛋白原水平与纤维蛋白原β（）-148C/T 基因多态性之间的关系。
本研究纳入 64 例 AD 患者、72 例 VaD 患者和 56 名健康对照者（HC）。采用比浊法检测血浆 Fg 水平。其中，64 例 AD 患者、52 例 VaD 患者和 56 名 HC 采用限制性片段长度多态性-PCR 法进行-148C/T 多态性分析。
AD 和 VaD 组的血浆 Fg 明显高于 HC 组。-148 TT 基因型的 AD 和 VaD 患者的血浆 Fg 明显高于 CC 或 CT 基因型患者。三组间 CC 和 CT+TT 基因型的分布不同，AD 患者 CT+TT 基因型的频率高于 HC 组。
血浆 Fg 水平与 AD 和 VaD 显著相关，与-148C/T 多态性有关。TT+CT 基因型和 T 等位基因的分布频率可能与 AD 有关。
