Ejma Maria, Waliszewska-Prosół Marta, Hofman Anna, Budrewicz Sławomir, Podemski Ryszard, Bilińska Małgorzata, Koszewicz Magdalena
Department of Neurology, Wrocław Medical University, Wrocław, Poland.
Department of Neurology, Wrocław Medical University, Wrocław, Poland.
Neurol Neurochir Pol. 2015;49(2):137-8. doi: 10.1016/j.pjnns.2015.03.002. Epub 2015 Mar 12.
Miller-Fisher Syndrome (MFS) is a rare acute polyneuropathy composed of the clinical triad of ataxia, areflexia and ophthalmoplegia, with a monophasic, self-limited course and spontaneous improvement.
The authors present a 65-year-old man with Miller-Fisher syndrome consisting of bilateral ophthalmoplegia, trigeminal and facial nerve palsy, mild ataxia and peripheral neuropathy. The disease had a progressive, subacute course within 3 months. A high titer of anti-GQ1b antibodies was detected. As a result of plasmapheresis, complete recovery was achieved.
The presented case was atypical in its clinical course and treatment. It could support the theory of the continuity between MFS, Bickerstaff brainstem encephalitis (BBE), and Guillain-Barré syndrome (GBS).
米勒-费希尔综合征（MFS）是一种罕见的急性多发性神经病，由共济失调、腱反射消失和眼肌麻痹三联征组成，病程呈单相性、自限性且可自发改善。
作者报告了一名65岁患有米勒-费希尔综合征的男性患者，其症状包括双侧眼肌麻痹、三叉神经和面神经麻痹、轻度共济失调和周围神经病变。该病在3个月内呈进行性、亚急性病程。检测到高滴度的抗GQ1b抗体。经过血浆置换治疗后，患者完全康复。
该病例在临床病程和治疗方面具有非典型性。它可以支持MFS、比克斯特法夫脑干脑炎（BBE）和格林-巴利综合征（GBS）之间存在连续性的理论。
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