Park U J, Hyun S K, Kim H T, Cho W H, Han S Y
Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea.
Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea.
Transplant Proc. 2015 Apr;47(3):791-3. doi: 10.1016/j.transproceed.2014.11.054.
Disseminated adenovirus infection in recipients of renal transplants is a rare but often fatal complication. We present a case of a 32-year-old woman who underwent renal transplantation from a deceased donor. Ten months after transplantation, she presented with dysuria, hematuria, and febrile illness. Despite the use of antibiotics, the patient's symptoms continued and worsened and the serum creatinine level was increased. The results of urine and serum polymerase chain reaction were positive for adenovirus. Renal biopsy revealed viral interstitial nephritis. The patient was treated with ribavirin, intravenous immunoglobulin, and reduction in immunosuppression. Her symptoms progressively improved from 7 days after the treatment. Serum and urine polymerase chain reaction for adenovirus became negative 10 and 21 days after the treatment, respectively. She remained in good health with excellent allograft function 6 months later.
肾移植受者的播散性腺病毒感染是一种罕见但往往致命的并发症。我们报告一例32岁女性，她接受了来自已故供体的肾移植。移植后10个月，她出现排尿困难、血尿和发热性疾病。尽管使用了抗生素，患者的症状仍持续并加重，血清肌酐水平升高。尿液和血清聚合酶链反应结果显示腺病毒呈阳性。肾活检显示病毒性间质性肾炎。患者接受了利巴韦林、静脉注射免疫球蛋白治疗，并减少了免疫抑制。治疗7天后她的症状逐渐改善。治疗后10天和21天，腺病毒的血清和尿液聚合酶链反应分别转为阴性。6个月后，她保持健康，移植肾功能良好。
