Gutiérrez-Escribano Pilar, Nurse Paul
Cell Cycle Laboratory Cancer Research UK London Research Institute, London WC2A 3LY, UK.
1] Cell Cycle Laboratory Cancer Research UK London Research Institute, London WC2A 3LY, UK [2] Laboratory of Yeast Genetics and Cell Biology, Rockefeller University, New York, New York 10065, USA [3] The Francis Crick Institute, London NW1 2BE, UK.
Nat Commun. 2015 Apr 20;6:6871. doi: 10.1038/ncomms7871.
The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities. However, in fission yeast it has been shown that a single CDK complex generated by the fusion of the Cdc13 cyclin with the CDK protein Cdc2 can drive the mitotic cell cycle. Meiosis is a modified cell cycle programme in which a single S-phase is followed by two consecutive rounds of chromosome segregation. Here we systematically analyse the requirements of the different fission yeast cyclins for meiotic cell cycle progression. We also show that a single Cdc13-Cdc2 complex, in the absence of the other cyclins, can drive the meiotic cell cycle. We propose that qualitatively different CDK complexes are not absolutely required for cell cycle progression either during mitosis or meiosis, and that a single CDK complex can drive both cell cycle programmes.
真核细胞周期调控的主流模型认为，细胞周期进程是由一系列具有不同底物特异性的CDK复合物驱动的。然而，在裂殖酵母中，研究表明由Cdc13细胞周期蛋白与CDK蛋白Cdc2融合产生的单一CDK复合物可以驱动有丝分裂细胞周期。减数分裂是一种经过修饰的细胞周期程序，其中一个S期之后是两轮连续的染色体分离。在这里，我们系统地分析了裂殖酵母中不同细胞周期蛋白对减数分裂细胞周期进程的需求。我们还表明，在没有其他细胞周期蛋白的情况下，单一的Cdc13-Cdc2复合物可以驱动减数分裂细胞周期。我们提出，在有丝分裂或减数分裂期间，细胞周期进程并非绝对需要性质不同的CDK复合物，单一的CDK复合物可以驱动这两种细胞周期程序。
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