Ishidate Takao, Elewa Ahmed, Kim Soyoung, Mello Craig C, Shirayama Masaki
RNA Therapeutics Institute; University of Massachusetts Medical School; Worcester, MA USA; Howard Hughes Medical Institute; University of Massachusetts Medical School; Worcester, MA USA.
RNA Therapeutics Institute; University of Massachusetts Medical School; Worcester, MA USA.
Cell Cycle. 2014;13(9):1384-91. doi: 10.4161/cc.28656. Epub 2014 Mar 26.
The elegant choreography of metazoan development demands exquisite regulation of cell-division timing, orientation, and asymmetry. In this review, we discuss studies in Drosophila and C. elegans that reveal how the cell cycle machinery, comprised of cyclin-dependent kinase (CDK) and cyclins functions as a master regulator of development. We provide examples of how CDK/cyclins: (1) regulate the asymmetric localization and timely destruction of cell fate determinants; (2) couple signaling to the control of cell division orientation; and (3) maintain mitotic zones for stem cell proliferation. These studies illustrate how the core cell cycle machinery should be viewed not merely as an engine that drives the cell cycle forward, but rather as a dynamic regulator that integrates the cell-division cycle with cellular differentiation, ensuring the coherent and faithful execution of developmental programs.
后生动物发育过程中精妙的细胞活动编排需要对细胞分裂的时间、方向和不对称性进行精确调控。在这篇综述中，我们讨论了在果蝇和秀丽隐杆线虫中的研究，这些研究揭示了由细胞周期蛋白依赖性激酶（CDK）和细胞周期蛋白组成的细胞周期机制如何作为发育的主要调节因子发挥作用。我们举例说明了CDK/细胞周期蛋白如何：（1）调节细胞命运决定因子的不对称定位和及时降解；（2）将信号传导与细胞分裂方向的控制联系起来；（3）维持用于干细胞增殖的有丝分裂区域。这些研究表明，核心细胞周期机制不应仅仅被视为推动细胞周期前进的引擎，而应被视为一种动态调节因子，它将细胞分裂周期与细胞分化整合在一起，确保发育程序的连贯和准确执行。
