Chia-Yi Hospital, Ministry of Health and Welfare, 600 Chiayi City, Taiwan.
Tsaotun Psychiatric Center, Ministry of Health and Welfare, 54249 Nantou County, Taiwan; Department of Public Health and Institute of Public Health, National Yang-Ming University, 112 Taipei City, Taiwan.
Gen Hosp Psychiatry. 2015 Jul-Aug;37(4):294-8. doi: 10.1016/j.genhosppsych.2015.04.003. Epub 2015 Apr 8.
We conducted this nationwide study to examine the epidemiology of hyperlipidemia among Taiwanese patients with bipolar disorder.
We used a random sample of 766,427 subjects who were ≥18 years old in 2005. Subjects with at least one primary diagnosis of bipolar disorder were identified. Individuals with a primary or secondary diagnosis of hyperlipidemia or medication treatment for hyperlipidemia were also identified. We compared the prevalence of hyperlipidemia in patients with bipolar disorder with the general population in 2005. Furthermore, we investigated this cohort from 2006 to 2010 to detect the incident cases of hyperlipidemia.
The prevalence of hyperlipidemia in patients with bipolar disorder was higher than that of the general population [13.5% vs. 7.9%; odds ratio, 1.75; 95% confidence interval (CI), 1.52-2.02] in 2005. The average annual incidence of hyperlipidemia in patients with bipolar disorder was also higher than that of the general population (4.37% vs. 2.55%; risk ratio, 1.66; 95% CI, 1.47-1.87) from 2006 to 2010.
Patients with bipolar disorder had a higher prevalence and incidence of hyperlipidemia compared with the general population. Patients with bipolar disorder coexisting hypertension exhibited a higher likelihood of hyperlipidemia.
我们进行了这项全国性研究，以调查台湾地区双相情感障碍患者的血脂异常流行病学。
我们使用了 2005 年年龄在 18 岁及以上的 766427 名随机样本。确定了至少有一次双相情感障碍主要诊断的患者。还确定了有血脂异常的主要或次要诊断或血脂异常药物治疗的患者。我们比较了 2005 年双相情感障碍患者的血脂异常患病率与普通人群的患病率。此外，我们从 2006 年到 2010 年调查了这一队列，以发现血脂异常的新发病例。
2005 年，双相情感障碍患者的血脂异常患病率高于普通人群（13.5%比 7.9%；优势比，1.75；95%置信区间（CI），1.52-2.02）。2006 年至 2010 年，双相情感障碍患者的血脂异常平均年发病率也高于普通人群（4.37%比 2.55%；风险比，1.66；95%CI，1.47-1.87）。
与普通人群相比，双相情感障碍患者的血脂异常患病率和发病率更高。伴发高血压的双相情感障碍患者更有可能发生血脂异常。
