双相障碍女性患者异常糖脂代谢、生殖激素与认知功能障碍的相关性研究。
Association among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder.
机构信息
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
出版信息
BMC Psychiatry. 2024 May 21;24(1):385. doi: 10.1186/s12888-024-05831-y.
BACKGROUND
Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern in women with BD. This study was dedicated to investigating the glucolipid and reproductive hormone levels of female patients, and to preliminarily investigating their relationships with cognition.
METHODS
A total of 58 unmedicated female BD patients, 61 stable-medicated female BD patients, and 63 healthy controls (HC) were recruited in this study. Serum glycolipid indexes and reproductive hormones were measured. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Stroop Color-Word Test (Stroop test).
RESULTS
Patients with BD showed significant cognitive impairment (p < 0.05), which was not affected by medication. Triglycerides (TG), luteinizing hormone (LH), and high-density lipoprotein cholesterol (HDL-c) were altered in stable-medicated BD patients. In addition, regression analysis showed that progesterone (PRGE) and prolactin (PRL) were negatively associated with cognitive performance in stable-medicated BD patients.
CONCLUSIONS
Female BD patients may have cognitive deficits and abnormal levels of glycolipids and reproductive hormones. And abnormal levels of glycolipids and reproductive hormones may be associated with cognitive dysfunction in female BD patients.
背景
双相情感障碍（BD）患者的糖脂代谢和生殖激素水平存在异常，这是 BD 女性患者关注的问题。本研究旨在调查女性 BD 患者的糖脂和生殖激素水平，并初步探讨其与认知功能的关系。
方法
本研究共纳入 58 名未经药物治疗的女性 BD 患者、61 名稳定期药物治疗的女性 BD 患者和 63 名健康对照者（HC）。测量血清糖脂指标和生殖激素。使用重复认知评估系统（RBANS）和斯特鲁普色词测验（Stroop 测验）评估认知功能。
结果
BD 患者存在明显的认知障碍（p<0.05），且不受药物影响。稳定期药物治疗的 BD 患者的甘油三酯（TG）、黄体生成素（LH）和高密度脂蛋白胆固醇（HDL-c）发生改变。此外，回归分析显示，稳定期药物治疗的 BD 患者孕激素（PRGE）和催乳素（PRL）与认知表现呈负相关。
结论
女性 BD 患者可能存在认知缺陷和糖脂代谢及生殖激素水平异常，且糖脂代谢和生殖激素水平异常可能与女性 BD 患者的认知功能障碍有关。
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