Chia-Yi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan.
Bali Psychiatric Center, Ministry of Health and Welfare, New Taipei, Taiwan; National Yang-Ming University, Taipei, Taiwan.
J Affect Disord. 2021 Feb 15;281:721-726. doi: 10.1016/j.jad.2020.11.083. Epub 2020 Nov 13.
This study investigated the national prevalence and incidence of ischemic heart disease and associated factors among Taiwanese patients with bipolar disorder.
We used a random sample of 766,427 subjects who were ≥18 years old from the National Health Research Institute database in 2005. Subjects with at least one primary diagnosis of bipolar disorder or ischemic heart disease were identified. We compared the prevalence and incidence of ischemic heart disease in bipolar patients and the general population in 2005 and the same cohort from 2006 to 2010. These associated factors with respect to ischemic heart disease among patients with bipolar disorder were also analyzed.
The prevalence of ischemic heart disease in patients with bipolar disorder was 1.69 times higher than in the general population (7.85% vs 4.67%; odds ratio 1.69; 95% confidence interval, 1.41-2.03) in 2005. The average annual incidence of ischemic heart disease in patients with bipolar disorder was also 1.60 times higher than in the general population (2.02% vs 1.24; risk ratio 1.60; 95% confidence interval, 1.36-1.90) from 2006 to 2010. The higher prevalence of ischemic heart disease among bipolar patients was associated with increased age, diabetes, hypertension, and antidepressant use.
Patients with bipolar disorder had a significantly higher prevalence and incidence of ischemic heart disease than the general population in both sexes, especially at younger ages. Among patients with bipolar disorder, older age, and hyperlipidemia were risk factors of ischemic heart disease.
本研究旨在调查台湾地区双相障碍患者缺血性心脏病的全国患病率和发病率及其相关因素。
我们使用了国家健康研究机构数据库中 2005 年年龄≥18 岁的 766427 名随机样本。确定了至少有一次双相障碍或缺血性心脏病主要诊断的患者。我们比较了 2005 年双相患者和一般人群中缺血性心脏病的患病率和发病率，以及 2006 年至 2010 年同一队列的发病率。还分析了双相障碍患者缺血性心脏病的相关因素。
2005 年，双相障碍患者缺血性心脏病的患病率是一般人群的 1.69 倍（7.85%对 4.67%；优势比 1.69；95%置信区间 1.41-2.03）。从 2006 年至 2010 年，双相障碍患者缺血性心脏病的平均年发病率也高于一般人群（2.02%对 1.24%；风险比 1.60；95%置信区间 1.36-1.90）。双相患者中缺血性心脏病的患病率较高与年龄增长、糖尿病、高血压和抗抑郁药的使用有关。
在两性中，与一般人群相比，双相障碍患者的缺血性心脏病患病率和发病率均显著更高，尤其是在较年轻的年龄组中。在双相障碍患者中，年龄较大和血脂异常是缺血性心脏病的危险因素。
