血清镁而非维生素D与慢性阻塞性肺疾病（COPD）患者更好的生活质量相关：一项横断面研究。

Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study.

作者信息

Hashim Ali Hussein Sarah, Nielsen Lars Peter, Konow Bøgebjerg Dolberg Mette, Dahl Ronald

机构信息

Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark.

Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Respir Med. 2015 Jun;109(6):727-33. doi: 10.1016/j.rmed.2015.03.005. Epub 2015 Mar 27.

DOI:10.1016/j.rmed.2015.03.005

PMID:25892292

Abstract

BACKGROUND

Deficiency of serum levels of vitamin D3 (se vitD), magnesium (se Mg) and calcium (se Ca) may be associated with increased exacerbation risk in chronic obstructive pulmonary disease (COPD). However, associations with other aspects of COPD, e.g. lung function and quality of life (QoL), have been studied less extensively.

AIM

To investigate se vitD, se Mg and se Ca in COPD and their associations with both forced expiratory volume in 1st second (FEV1) and QoL.

METHODS

FEV1 and se vitD (assessed by 25-(OH)-D3), se Mg and se Ca were measured during summertime. Generic and health related QoL were characterized.

RESULTS

This cross-sectional study included 143 participants with COPD. Women had a significantly higher se vitD than men (P = 0.0028), and 27% of participants were se vitD deficient. FEV1 was not correlated with se vitD, se Mg or se Ca in COPD. Mg deficiency group reported significantly impaired mobility, usual activities, pain/discomfort and COPD-related QoL. Se vitD and se Ca were not associated with QoL.

CONCLUSION

Serum levels of vitD, Mg and Ca were not related to FEV1. Most participants in this study were vitD-, Mg- and Ca sufficient. Women had higher se vitD than men. Se Mg, but not se vitD and se Ca, was associated with QoL in COPD. Prospective randomized studies are needed to substantiate these finding. Clinical trials ID at www.clinicaltrials.gov: NCT01564953.

摘要

背景

血清维生素D3（se vitD）、镁（se Mg）和钙（se Ca）水平缺乏可能与慢性阻塞性肺疾病（COPD）急性加重风险增加有关。然而，关于它们与COPD其他方面，如肺功能和生活质量（QoL）的关联研究较少。

目的

研究COPD患者的se vitD、se Mg和se Ca及其与第1秒用力呼气量（FEV1）和QoL的关系。

方法

在夏季测量FEV1以及se vitD（通过25-（OH）-D3评估）、se Mg和se Ca。对一般和与健康相关的QoL进行特征描述。

结果

这项横断面研究纳入了143名COPD患者。女性的se vitD显著高于男性（P = 0.0028），27%的参与者存在se vitD缺乏。COPD患者的FEV1与se vitD、se Mg或se Ca均无相关性。镁缺乏组报告在活动能力、日常活动、疼痛/不适和与COPD相关的QoL方面有显著受损。Se vitD和se Ca与QoL无关。

结论

血清vitD、Mg和Ca水平与FEV1无关。本研究中的大多数参与者vitD、Mg和Ca充足。女性的se vitD高于男性。Se Mg而非se vitD和se Ca与COPD患者的QoL相关。需要进行前瞻性随机研究来证实这些发现。临床试验编号可在www.clinicaltrials.gov查询：NCT01564953。