非典型转录因子E2F8在小鼠和人类蜕膜化过程中的多倍体化作用。
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
作者信息
Qi Qian-Rong, Zhao Xu-Yu, Zuo Ru-Juan, Wang Tong-Song, Gu Xiao-Wei, Liu Ji-Long, Yang Zeng-Ming
机构信息
a College of Veterinary Medicine; South China Agricultural University ; Guangzhou , China.
出版信息
Cell Cycle. 2015;14(12):1842-58. doi: 10.1080/15384101.2015.1033593.
Abstract
Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans.
摘要
多倍体蜕膜细胞是小鼠子宫蜕膜化过程中特化的细胞。然而，关于妊娠过程中多倍体化的调控机制和生理意义，我们知之甚少。在此，我们报道了E2F8在小鼠蜕膜细胞多倍体化中的新作用。E2F8在蜕膜细胞中高表达，并通过HB-EGF/EGFR/ERK/STAT3信号通路受孕酮调控。E2F8转录抑制CDK1，从而触发蜕膜细胞的多倍体化。E2F8介导的多倍体化是对伴随蜕膜化的应激的一种反应。有趣的是，在人蜕膜化过程中，随着E2F8的下调未检测到多倍体化，这表明E2F8的差异表达可能导致小鼠和人之间蜕膜细胞多倍体化的差异。
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本文引用的文献
1
Minireview: Steroid-regulated paracrine mechanisms controlling implantation.小型综述：类固醇调节的旁分泌机制控制着床
Mol Endocrinol. 2014 Sep;28(9):1408-22. doi: 10.1210/me.2014-1074. Epub 2014 Jul 22.
2
Crystallin αB acts as a molecular guard in mouse decidualization: regulation and function during early pregnancy.晶状体αB在小鼠蜕膜化过程中起分子保护作用：早期妊娠期间的调节与功能
FEBS Lett. 2014 Aug 25;588(17):2944-51. doi: 10.1016/j.febslet.2014.05.045. Epub 2014 Jun 18.
3
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.表皮生长因子受体在妊娠早期对子宫内膜功能起着关键调节作用。
PLoS Genet. 2014 Jun 19;10(6):e1004451. doi: 10.1371/journal.pgen.1004451. eCollection 2014 Jun.
4
Heparin-binding epidermal growth factor-like growth factor: a hepatic stellate cell proliferation inducer via ErbB receptors.肝素结合表皮生长因子样生长因子：一种通过ErbB受体诱导肝星状细胞增殖的因子。
J Gastroenterol Hepatol. 2014 Mar;29(3):623-32. doi: 10.1111/jgh.12412.
5
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PLoS One. 2013 Sep 24;8(9):e75282. doi: 10.1371/journal.pone.0075282. eCollection 2013.
6
Physiological significance of polyploidization in mammalian cells.多倍体化在哺乳动物细胞中的生理意义。
Trends Cell Biol. 2013 Nov;23(11):556-66. doi: 10.1016/j.tcb.2013.06.002. Epub 2013 Jul 10.
7
New insights into mechanisms behind miscarriage.对流产背后机制的新认识。
BMC Med. 2013 Jun 26;11:154. doi: 10.1186/1741-7015-11-154.
8
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9
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Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9368-73. doi: 10.1073/pnas.1304889110. Epub 2013 Apr 23.
10
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