Gawlik Aneta, Such Kamila, Dejner Aleksandra, Zachurzok Agnieszka, Antosz Aleksandra, Malecka-Tendera Ewa
Department of Pediatrics, Pediatric Endocrinology and Diabetes, School of Medicine in Katowice, Medical University of Silesia, 40752 Katowice, Poland.
Medical Students' Scientific Association, 40752 Katowice, Poland.
Int J Endocrinol. 2015;2015:691071. doi: 10.1155/2015/691071. Epub 2015 Mar 29.
Although subclinical hypothyroidism (SH) is a common clinical problem, its diagnosis tends to be incidental. According to the definition, it should be asymptomatic, only detectable by screening. The presence or coincidence of any symptoms leads to L-thyroxine treatment. The clinical presentation, especially in younger patients with subclinical hypothyroidism, is still under dispute. Accordingly, the aim of this paper was to review the literature from the past seven years. The literature search identified 1,594 potentially relevant articles, of which 24 met the inclusion criteria. Few studies focus on the symptomatology of subclinical hypothyroidism, and most of them analyzed a small number of subjects. A significant correlation was found by some authors between subclinical hypothyroidism and a higher risk of hypertension, dyslipidemia, and migraine. No evidence of the impact of subclinical hypothyroidism on weight, growth velocity, and puberty was revealed. As the quality of most studies is poor and no definite conclusions can be drawn, randomized, large-scale studies in children and adolescents are warranted to determine the best care for patients with SH.
虽然亚临床甲状腺功能减退（SH）是一个常见的临床问题，但其诊断往往是偶然的。根据定义，它应该是无症状的，只能通过筛查检测到。任何症状的出现或并发都会导致左甲状腺素治疗。其临床表现，尤其是在患有亚临床甲状腺功能减退的年轻患者中，仍存在争议。因此，本文的目的是回顾过去七年的文献。文献检索共识别出1594篇可能相关的文章，其中24篇符合纳入标准。很少有研究关注亚临床甲状腺功能减退的症状学，而且大多数研究分析的受试者数量较少。一些作者发现亚临床甲状腺功能减退与高血压、血脂异常和偏头痛的较高风险之间存在显著相关性。未发现亚临床甲状腺功能减退对体重、生长速度和青春期有影响的证据。由于大多数研究质量较差，无法得出明确结论，因此有必要开展针对儿童和青少年的随机、大规模研究，以确定对亚临床甲状腺功能减退患者的最佳治疗方案。
