Pedullà Marcella, Fierro Vincenzo, Marzuillo Pierluigi, Del Tufo Ester, Grandone Anna, Perrone Laura, Miraglia Del Giudice Emanuele
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna Grandone, Laura Perrone, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
World J Clin Pediatr. 2016 Aug 8;5(3):306-10. doi: 10.5409/wjcp.v5.i3.306.
To verify if subclinical hypothyroidism (SCH) could be associated to atopy in children.
Seven hundred and thirty-two Caucasian children from South Italy presenting symptoms of allergic disease were enrolled and submitted to atopy, obesity, chronic low grade inflammation, and SCH work up.
Four hundred and forty-five out of 705 (63.12%) children affected by allergic disease were diagnosed as atopic and 260 (36.88%) as not atopic. The SCH prevalence was 6.3%. Significant higher prevalence of SCH among atopic children with average (group 2) and high (group 3) low grade chronic inflammation compared to atopic children with mild (group 1) low grade chronic inflammation was present. Moreover, group 1 and group 2 presented an OR to show SCH of 2.57 (95%CI: 1.55-6.26) and 2.96 (95%CI: 1.01-8.65), respectively. Both in atopic and not atopic children we found C3 serum levels significantly higher in group 3 respect to group 2 and group 1. Noteworthy, among atopic patients, also total immunoglobulin E (IgE) serum levels, were significantly higher in group 3 compared to group 2 and group 1 children. In atopic children, C3 and total IgE serum values increased in parallel with the increase of C-reactive protein values, while in not atopic children this phenomenon was not evident.
The possibility exists that an increasing atopic inflammation contributes to SCH occurrence. So far this is the first report in literature showing an association between SCH and atopy but further studies are needed to confirm our data.
验证亚临床甲状腺功能减退症（SCH）是否与儿童特应性疾病相关。
招募了732名来自意大利南部有过敏性疾病症状的白种儿童，对其进行特应性疾病、肥胖、慢性低度炎症和SCH检查。
705名患有过敏性疾病的儿童中，445名（63.12%）被诊断为特应性疾病，260名（36.88%）为非特应性疾病。SCH患病率为6.3%。与轻度（第1组）慢性低度炎症的特应性儿童相比，中度（第2组）和重度（第3组）慢性低度炎症的特应性儿童中SCH患病率显著更高。此外，第1组和第2组显示患SCH的比值比分别为2.57（95%可信区间：1.55 - 6.26）和2.96（95%可信区间：1.01 - 8.65）。在特应性和非特应性儿童中，我们发现第3组的C3血清水平显著高于第2组和第1组。值得注意的是，在特应性患者中，第3组的总免疫球蛋白E（IgE）血清水平也显著高于第2组和第1组儿童。在特应性儿童中，C3和总IgE血清值随C反应蛋白值的增加而平行升高，而在非特应性儿童中这种现象不明显。
存在特应性炎症增加导致SCH发生的可能性。到目前为止，这是文献中首次报道SCH与特应性疾病之间的关联，但需要进一步研究来证实我们的数据。
