• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

营养诱导的2型和化学诱导的1型实验性糖尿病对胃胰高血糖素样肽-1受体表达的调节方式不同。

Nutrient induced type 2 and chemical induced type 1 experimental diabetes differently modulate gastric GLP-1 receptor expression.

作者信息

Bloch Olga, Broide Efrat, Ben-Yehudah Gilad, Cantrell Dror, Shirin Haim, Rapoport Micha J

机构信息

Diabetes and Immunology Research Laboratory, Assaf Harofeh Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 70300 Zerifin, Israel.

Institute of Gastroenterology, Assaf Harofeh Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 70300 Zerifin, Israel.

出版信息

J Diabetes Res. 2015;2015:561353. doi: 10.1155/2015/561353. Epub 2015 Mar 29.

DOI:10.1155/2015/561353
PMID:25893200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4393893/
Abstract

T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2DM and T1DM were induced in Psammomys obesus (PO) by high-energy (HE) diet and by streptozotocin (STZ) in Sprague Dawly (SD) rats, respectively. GLP-1R expression was determined in glandular stomach by RT PCR and immunohistomorphological analysis. The mRNA expression and cellular association of the GLP-1R in principal glands were similar in control PO and SD rats. However, nutrient and chemical induced diabetes resulted in opposite alterations of glandular GLP-1R expression. Diabetic PO demonstrated increased GLP-1R mRNA expression, intensity of cellular GLP-1R immunostaining, and frequency of GLP-1R positive cells in the neck area of principal glands compared with controls. In contrast, SD diabetic rats demonstrated decreased GLP-1 mRNA, cellular GLP-1R immunoreactivity, and frequency of GLP-1R immunoreactive cells in the neck area compared with controls. In conclusion, nutrient and chemical induced experimental diabetes result in distinct opposite alterations of GLP-1R expression in glandular stomach. These results suggest that induced T1DM and T2DM may differently modulate GLP-1R system in enteropancreatic axis.

摘要

2型糖尿病（T2DM）患者胃腺中的胰高血糖素样肽-1受体（GLP-1R）表达降低。诱导性T2DM和1型糖尿病（T1DM）对胃GLP-1R表达的影响是否不同尚不清楚。本研究评估了不同类型实验性糖尿病啮齿动物腺胃中的胰腺外GLP-1R系统。分别通过高能（HE）饮食诱导肥胖沙鼠（PO）发生T2DM，通过链脲佐菌素（STZ）诱导斯普拉格-道利（SD）大鼠发生T1DM。通过逆转录聚合酶链反应（RT PCR）和免疫组织形态学分析测定腺胃中的GLP-1R表达。对照PO和SD大鼠主腺中GLP-1R的mRNA表达和细胞关联相似。然而，营养和化学诱导的糖尿病导致腺GLP-1R表达出现相反的变化。与对照组相比，糖尿病PO在主腺颈部区域的GLP-1R mRNA表达增加、细胞GLP-1R免疫染色强度增加以及GLP-1R阳性细胞频率增加。相反，与对照组相比，SD糖尿病大鼠颈部区域的GLP-1 mRNA、细胞GLP-1R免疫反应性以及GLP-1R免疫反应性细胞频率降低。总之，营养和化学诱导的实验性糖尿病导致腺胃中GLP-1R表达出现明显相反的变化。这些结果表明，诱导性T1DM和T2DM可能对肠胰轴中的GLP-1R系统产生不同的调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/4944ff03aab6/JDR2015-561353.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/50e76e347872/JDR2015-561353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/2de20a1653cf/JDR2015-561353.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/4dac9b8feed2/JDR2015-561353.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/195eab1cee5b/JDR2015-561353.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/4944ff03aab6/JDR2015-561353.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/50e76e347872/JDR2015-561353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/2de20a1653cf/JDR2015-561353.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/4dac9b8feed2/JDR2015-561353.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/195eab1cee5b/JDR2015-561353.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f8/4393893/4944ff03aab6/JDR2015-561353.005.jpg

相似文献

1
Nutrient induced type 2 and chemical induced type 1 experimental diabetes differently modulate gastric GLP-1 receptor expression.营养诱导的2型和化学诱导的1型实验性糖尿病对胃胰高血糖素样肽-1受体表达的调节方式不同。
J Diabetes Res. 2015;2015:561353. doi: 10.1155/2015/561353. Epub 2015 Mar 29.
2
Reduced GLP-1R expression in gastric glands of patients with type 2 diabetes mellitus.
J Clin Endocrinol Metab. 2014 Sep;99(9):E1691-5. doi: 10.1210/jc.2014-1114. Epub 2014 May 30.
3
GLP-1 receptor is expressed in human stomach mucosa: analysis of its cellular association and distribution within gastric glands.GLP-1 受体在人胃黏膜中表达：其在胃腺内细胞相关性和分布的分析。
J Histochem Cytochem. 2013 Sep;61(9):649-58. doi: 10.1369/0022155413497586. Epub 2013 Jun 26.
4
Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats.艾塞那肽-4和硒对糖尿病大鼠胰腺中胰高血糖素样肽-1受体（GLP-1R）、胰岛素受体底物-1（IRS-1）和胰岛素原表达的影响。
J Physiol Biochem. 2016 Aug;73(3):387-394. doi: 10.1007/s13105-017-0565-1. Epub 2017 Jun 7.
5
Fractionated whole body gamma irradiation modulates the hepatic response in type II diabetes of high fat diet model rats.分次全身γ射线照射可调节高脂饮食模型大鼠II型糖尿病中的肝脏反应。
Mol Biol Rep. 2019 Apr;46(2):2273-2283. doi: 10.1007/s11033-019-04681-2. Epub 2019 Feb 12.
6
Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.2型糖尿病患者胰腺中胰高血糖素样肽1受体（GLP-1R）表达的免疫组织化学评估
Diabetes Obes Metab. 2017 May;19(5):705-712. doi: 10.1111/dom.12879. Epub 2017 Mar 10.
7
CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin.西他列汀治疗糖尿病大鼠肝脏中 CB-1R 和 GLP-1R 基因表达和氧化应激。
Pharmacol Rep. 2017 Aug;69(4):822-829. doi: 10.1016/j.pharep.2017.03.013. Epub 2017 Mar 20.
8
Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model.胰高血糖素样肽-1减轻大鼠糖尿病模型中的肝损伤。
Pak J Pharm Sci. 2019 Jan;32(1(Supplementary)):309-313.
9
Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses.胰高血糖素样肽-1 受体的激活通过减轻神经炎症反应促进实验性自身免疫性脑脊髓炎的神经保护作用。
Mol Neurobiol. 2018 Apr;55(4):3007-3020. doi: 10.1007/s12035-017-0550-2. Epub 2017 Apr 29.
10
GLP-1 Treatment Improves Diabetic Retinopathy by Alleviating Autophagy through GLP-1R-ERK1/2-HDAC6 Signaling Pathway.GLP-1 治疗通过 GLP-1R-ERK1/2-HDAC6 信号通路减轻自噬改善糖尿病视网膜病变。
Int J Med Sci. 2017 Sep 19;14(12):1203-1212. doi: 10.7150/ijms.20962. eCollection 2017.

引用本文的文献

1
Comparison of Exendin-4 and Its Single Amino Acid Substitutions as Parent Peptides for GLP-1 Receptor Imaging Probes.艾塞那肽-4及其单氨基酸取代物作为胰高血糖素样肽-1受体成像探针的母体肽的比较。
Molecules. 2025 Feb 21;30(5):1011. doi: 10.3390/molecules30051011.
2
A mathematical model reveals sex-specific changes in glucose and insulin tolerance during rat puberty and maturation.一个数学模型揭示了大鼠青春期和成熟期葡萄糖和胰岛素耐受性的性别特异性变化。
Croat Med J. 2020 Apr 30;61(2):107-118. doi: 10.3325/cmj.2020.61.107.
3
Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.

本文引用的文献

1
Reduced GLP-1R expression in gastric glands of patients with type 2 diabetes mellitus.
J Clin Endocrinol Metab. 2014 Sep;99(9):E1691-5. doi: 10.1210/jc.2014-1114. Epub 2014 May 30.
2
Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans.实验动物中链脲佐菌素攻击导致细胞死亡的机制、其实际应用及对人类的潜在风险综述。
J Diabetes Metab Disord. 2013 Dec 23;12(1):60. doi: 10.1186/2251-6581-12-60.
3
Rationale use of GLP-1 receptor agonists in patients with type 1 diabetes.GLP-1 受体激动剂在 1 型糖尿病患者中的合理应用。
胃旁路术对袖状胃切除术大鼠模型葡萄糖代谢的额外影响。
Surg Today. 2019 Jul;49(7):637-644. doi: 10.1007/s00595-019-1772-x. Epub 2019 Jan 31.
Curr Diab Rep. 2013 Oct;13(5):663-8. doi: 10.1007/s11892-013-0404-x.
4
GLP-1 receptor is expressed in human stomach mucosa: analysis of its cellular association and distribution within gastric glands.GLP-1 受体在人胃黏膜中表达：其在胃腺内细胞相关性和分布的分析。
J Histochem Cytochem. 2013 Sep;61(9):649-58. doi: 10.1369/0022155413497586. Epub 2013 Jun 26.
5
Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion.胰岛素抵抗小鼠胰岛素分泌增加：胰岛 GLP1 受体水平升高和 GPR119 激活的 GLP1 分泌增加的证据。
Endocr Connect. 2013 Mar 18;2(2):69-78. doi: 10.1530/EC-12-0079. Print 2013 Jun 1.
6
In vivo imaging of the glucagonlike peptide 1 receptor in the pancreas with 68Ga-labeled DO3A-exendin-4.用 68Ga 标记的 DO3A-exendin-4 对胰腺中的胰高血糖素样肽 1 受体进行体内成像。
J Nucl Med. 2013 Aug;54(8):1458-63. doi: 10.2967/jnumed.112.114066. Epub 2013 Jun 12.
7
Type 1 diabetes treatment beyond insulin: role of GLP-1 analogs.1 型糖尿病的胰岛素治疗以外：GLP-1 类似物的作用。
J Investig Med. 2013 Jan;61(1):40-4. doi: 10.2310/JIM.0b013e318279b7d6.
8
Impaired secretion of total glucagon-like peptide-1 in people with impaired fasting glucose combined impaired glucose tolerance.空腹血糖受损合并葡萄糖耐量受损人群中胰高血糖素样肽-1 总分泌受损。
Int J Med Sci. 2012;9(7):574-81. doi: 10.7150/ijms.4128. Epub 2012 Sep 7.
9
The use of animal models in diabetes research.在糖尿病研究中使用动物模型。
Br J Pharmacol. 2012 Jun;166(3):877-94. doi: 10.1111/j.1476-5381.2012.01911.x.
10
Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus.基于肠促胰岛素的治疗：治疗 2 型糖尿病的有力且有前景的武器。
Diabetes Ther. 2011 May;2(2):101-21. doi: 10.1007/s13300-011-0002-3. Epub 2011 Feb 28.